Results 51 to 60 of about 3,908,770 (297)

Comparative genomics of nuclear envelope proteins [PDF]

BMC Genomics, 2018
The nuclear envelope (NE) that encapsulates the nuclear genome is a double lipid bilayer with several integral and peripherally associated proteins. It is a characteristic feature of the eukaryotes and acts as a hub for a number of important nuclear events including transcription, repair, and regulated gene expression.
Hita Sony Garapati, Krishnaveni Mishra
openaire   +3 more sources

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Frontiers in Pharmacology, 2023
Background and aims: Renal damage in severe coronavirus disease 2019 (COVID-19) is highly associated with mortality. Finding relevant therapeutic candidates that can alleviate it is crucial.
Shilin Zhou, Zanzhe Yu, Zihui Chen, Fengling Ning, Xuetao Hu, Tiangang Wu, Mingxue Li, Hong Xin, Svetlana Reilly, Xuemei Zhang   +9 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies

mBio
Antibodies targeting an envelope dimer epitope (EDE) cross-neutralize Zika virus (ZIKV) and dengue virus (DENV) and have thus inspired an epitope-focused vaccine design. There are two EDE antibody subclasses (EDE1, EDE2) distinguished by their dependence
Maya Contreras, Jackson B. Stuart, Lisa M. Levoir, Laura Belmont, Leslie Goo   +4 more
doaj   +1 more source

In-silico Antigenicity Determination and Clustering of Dengue Virus Serotypes

Frontiers in Genetics, 2018
Emerging or re-emerging dengue virus (DENV) causes dengue fever epidemics globally. Current DENV serotypes are defined based on genetic clustering, while discrepancies are frequently observed between the genetic clustering and the antigenicity ...
Jingxuan Qiu, Yuxuan Shang, Zhiliang Ji, Tianyi Qiu   +3 more
doaj   +1 more source

Partial Functional Rescue of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus Infectivity by Replacement of F Protein with GP64 from Autographa californica Multicapsid Nucleopolyhedrovirus [PDF]

, 2010
Two distinct envelope fusion proteins (EFPs) (GP64 and F) have been identified in members of the Baculoviridae family of viruses. F proteins are found in group II nucleopolyhedroviruses (NPVs) of alphabaculoviruses and in beta- and deltabaculoviruses ...
Feifei Yin, Shu Shen, Just M. Vlak, Fei Deng, Shen, S., Vlak, J.M., Deng, F., Manli Wang, Ying Tan, Yin, F.F., Hu, Z.H., Wang, M.L., Hualin Wang, Zhihong Hu, Tan, Y., Wang, H.L.   +15 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2

Journal of Virology
Porcine reproductive and respiratory syndrome viruses (PRRSVs) are significant pathogens that affect the global swine industry. Its virions consist of a central core composed of nucleocapsid (N) protein, surrounded by multiple distinct viral envelope ...
Yuan-Zhe Bai, Shujie Wang, Yue Sun, Yong-Gang Liu, Hong-Liang Zhang, Qian Wang, Rui Huang, Cui-Hong Rao, Shi-Jia Xu, Zhi-Jun Tian, Tong-Qing An, Xue-Hui Cai, Yan-Dong Tang   +12 more
doaj   +1 more source

Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein

Frontiers in Immunology, 2017
The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies.
Denicar Lina Nascimento Fabris Maeda, Milene Tavares Batista, Milene Tavares Batista, Lennon Ramos Pereira, Mariana de Jesus Cintra, Jaime Henrique Amorim, Camila Mathias-Santos, Sara Araújo Pereira, Silvia Beatriz Boscardin, Sandriana dos Ramos Silva, Eliana L. Faquim-Mauro, Vanessa Barbosa Silveira, Danielle Bruna Leal Oliveira, Stephen Albert Johnston, Luís Carlos de Souza Ferreira, Juliana Falcão Rodrigues   +15 more
doaj   +1 more source

Transcription of the Envelope Protein by 1-L Protein–RNA Recognition Code Leads to Genes/Proteins That Are Relevant to the SARS-CoV-2 Life Cycle and Pathogenesis

Current Issues in Molecular Biology, 2022
The theoretical protein–RNA recognition code was used in this study to research the compatibility of the SARS-CoV-2 envelope protein (E) with mRNAs in the human transcriptome.
Jozef Nahalka
doaj   +1 more source