Results 91 to 100 of about 354,863 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Product-Specific Environmental Information and Environmental Management Accounting

open access: yes, 2006
Product related environmental information is gaining increased attention, but todays generation and availability of such information could be significantly improved.
Erlandsson, Johan,
core  

A Consumption-Based Approach to Carbon Emission Accounting – Sectoral Differences and Environmental Benefits

open access: yes, 2013
In recent years there has been growing concern about the emission trade balances of countries. This is due to the fact that countries with an open economy are active players in international trade.
Vetőné Mózner, Zsófia
core   +1 more source

SfM-Based Method to Assess Gorgonian Forests (Paramuricea clavata (Cnidaria, Octocorallia))

open access: yesRemote Sensing, 2018
Animal forests promote marine habitats morphological complexity and functioning. The red gorgonian, Paramuricea clavata, is a key structuring species of the Mediterranean coralligenous habitat and an indicator species of climate effects on habitat ...
Marco Palma   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Accounting for Social and Environmental Sustainability [PDF]

open access: yes
For a company, managing its social and environmental performance is no longer just a matter of reducing its impact; it must also be able to assess its contribution to resolving or aggravating social and environmental problems.

core   +1 more source

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