Results 101 to 110 of about 354,863 (304)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Indicating Environmental Costs in Soil Pollution [PDF]

open access: yesحسابداری سلامت, 2014
Introduction: The aim of this research is examining the effective factors in contaminating soil, and the methods of disposal and prevention the soil from pollution; so that it would be possible to extract some indicators for calculating environmental ...
R. Hejazi, M. Taheri, K. Islami
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Modelling 'hard-to-measure' costs in environmental management accounting

open access: yes, 2006
This paper reviews measurement issues that have arisen in the environmental management accounting literature and provides a statistical approach to quantifying the financial results associated with vaguely defined outcomes from physical processes.
Willett, Roger   +2 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Evaluation of Environmental Accounting Methodologies for the assessment of global environmental impacts of traded goods and services.

open access: yes, 2010
Environmental accounting methods (EAM) are currently getting a strong interest from political entities, multinational corporations and citizens. EAMs are applied to a large range of socio-techno-economic activities for monitoring and managing their ...
Blanc, Isabelle, Friot, Damien
core   +1 more source

State and problems of development of environmental accounting: experience of Kazakhstan

open access: yesЭкономика: стратегия и практика, 2020
The article is dedicated to a comprehensive study of the development of the theory and methodology of environmental accounting. As a research task, the authors determined an attempt to assess the state of development of environmental accounting in the ...
F. K. Yerdavletova   +2 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

IMEA: IMports Environmental Accounting: towards an integrated framework

open access: yes, 2009
The ability of dealing with exchanges and regional specificities of existing Environmental Accounting Methodologies (EAM) e.g. LCA MFA environmental footprints or environmentally extended Input-Output is currently explored by national agencies as well as
Blanc, Isabelle   +5 more
core  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

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