Results 61 to 70 of about 5,498,816 (243)
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Productivity indicators applied to seabob shrimp fishing, Penha SC, Brazil
This study used environmental accounting tools to collect and organize information related to the market and work organization of the artisan fishing community of Penha, SC.
Vicente Francisco Coelho +2 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Environmental Accounting Disclosure Practices in Bangladesh and Its Impact on Investor Decisions [PDF]
The focus of this study is to identify the environmental disclosures made by Bangladeshi companies and analyze the overall disclosure practice of the countries’ industries.
Pizus Biswas +4 more
doaj
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
IMEA: IMports Environmental Accounting: towards an integrated framework
The ability of dealing with exchanges and regional specificities of existing Environmental Accounting Methodologies (EAM) e.g. LCA MFA environmental footprints or environmentally extended Input-Output is currently explored by national agencies as well as
Blanc, Isabelle +5 more
core +2 more sources
Environmental Management Accounting (Ema) Sebagai Dasar Pengukuran Dampak Usaha pada Perusahaan
To determine the environmental impact, cost and benefits of it’s conservation has done, this study will be explained descriptively. It used interview and documentary techniques in obtaining data, for example raw materials data, finished products and ...
Gomal Halomoan Nainggolan +2 more
doaj
This purpose of the researce to analyze of enviromental accounting and social responsibility, to improver the company performance by recording, classifying, summarizing and presenting the cost of social and environmental responsibility on the company's
Yusrotul Afiyah Manshur, Nawirah Nawirah
doaj +1 more source

