Results 131 to 140 of about 9,510,332 (304)

Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?

Particle and Fibre Toxicology
Background Exposure to air pollution including contemporary sources like wildland fire smoke worsens cardiovascular outcomes. Although several mechanisms for these effects have been postulated, one underexplored impact of inhaled air pollution that may ...
K. M. Rentschler, W. Kyle Martin, W. Oshiro, M. C. Schladweiler, T. W. Jackson, W. E. Cascio, U. P. Kodavanti, P. A. Evansky, C. Lambright, R. Strader, J. Conley, W. Williams, D. Freeborn, C. N. Miller, R. Grindstaff, M. Monsees, A. A. Lewis, D. W. Herr, P. R. S. Kodavanti, M. S. Hazari, A. K. Farraj   +20 more
doaj   +1 more source

Water Quality Criteria of Dieldrin for the Protection of Aquatic Organisms and Wildlife Using a Tissue Residue Approach

Toxics
Dieldrin is legacy organochlorine insecticide, which was listed in the Stockholm Convention because of its persistence, bioaccumulation and toxicity. However, it is still present in the environment and in organisms two decades after its ban.
Li Xie, Xuemei Li, Liangwen Bao, Yuexin Zhang, Hailei Su, Xuesong Liu, Fanfan Wang, Yuan Wei, Ningning Ji, Min Zhou   +9 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Multi-geoenvironmental assessment of heavy metal contamination and health risks in shallow aquifers near telecommunication masts

Discover Geoscience
Groundwater management is vital to community health and ecosystem sustainability. This study assessed the influence of telecommunication mast operations and maintenance activities on shallow groundwater quality in Ikare-Akoko, Nigeria, using an ...
Temitayo Olamide Ale, Adedibu Sunny Akingboye, Isaac Ayodele Ololade, Tolulope Henry Ogunribido, Oluyemi Emmanuel Faseki, Usman Ajani Abolade   +5 more
doaj   +1 more source

Pollution Characteristics, Toxicological Properties, and Health Risk Assessment of Phthalic Acid Esters in Water, Soil, and Atmosphere

Atmosphere
Phthalic acid esters (PAEs) are a class of common environmental endocrine disruptors (EEDs), capable of causing considerable pollution to water, soil, and air and producing a range of adverse health impacts in humans.
Fangyun Long, Yanqin Ren, Yuanyuan Ji, Junling Li, Haijie Zhang, Zhenhai Wu, Rui Gao, Fang Bi, Zhengyang Liu, Hong Li   +9 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Arctic Ocean Acidification Assessment: Summary for Policymakers [PDF]

, 2013
Executive summary of the 2013 Arctic Ocean Acidification Assessment, including an update on the state of ocean acidification in the Arctic and how that acidification is impacting on the Arctic marine environment. It outlines each of the ten key findings
Arctic Monitoring and Assessment Programme
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source