Results 111 to 120 of about 9,510,332 (304)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Codon usage bias is presumably affected by tRNA selection effects in Actinidia polyploidization events

BMC Genomics
Background Polyploidization is one of the main mechanisms in speciation, yet its effects on the frequency and distribution of synonymous codons remain unclear, which may lead to distinct patterns of codon usage bias (CUB) in polyploid species.
Yi Zhou, Zhilu Sheng, Dongbin Li, Wencui Li, Yujia Peng, Zhaopeng Song, Zhanjun Quan, Yongbo Liu   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Environmental Assessment

, 2022
Climate change is a current global problem, which is why numerous legislations are emerging, so that companies can have guidelines and tools to combat it. One of these tools is the LCA (Life Cycle Assessment) which aims to quantify the environmental impact of a product.
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Environmental Assessment--FY 1979 Winter Navigation Demonstration on the St. Lawrence River--Technical Reports: Volume I; TR-B. Benthic Sampling and Substrate Analysis at Ice Boom Sites I. Benthic Invertebrate Populations.

, 2010
Environmental Assessment--Benthic Sampling and Substrate Analysis at Ice Boom Sites I. Benthic Invertebrate Populations.This report taken together with companion report Volume I TR-C provides a comprehensive profile of the physical, chemical and ...
New York (State). Dept. of Environmental Conservation, SUNY College of Environmental Science and Forestry
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Environmental Assessment--FY 1979 Winter Navigation Demonstration on the St. Lawrence River--Technical Reports: Volume II; TR-L. Aquatic Food Web Characterization Studies.

, 2010
Volume Two of the Environmental Assessment of the proposed FY 1979 Winter Navigation Demonstration on the St. Lawrence River.Data gathered were reviewed and utilized to generate a preliminary concept of the aquatic ecosystem of the St. Lawrence River. A
New York (State). Dept. of Environmental Conservation, SUNY College of Environmental Science and Forestry
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Environmental Assessment--FY 1979 Winter Navigation Demonstration on the St. Lawrence River--Technical Reports: Volume II; TR-J. Amphibians and Reptiles Studies along the Demonstration Corridor.

, 2010
Environmental Assessment--Amphibians and Reptiles Studies along the Demonstration Corridor.Any impacts that results in disturbance at the wetland/water interface would probably impact herptiles.
New York (State). Dept. of Environmental Conservation, SUNY College of Environmental Science and Forestry
core