Results 41 to 50 of about 9,510,332 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dealing with uncertainties in environmental burden of disease assessment [PDF]

, 2009
Disability Adjusted Life Years (DALYs) combine the number of people affected by disease or mortality in a population and the duration and severity of their condition into one number.
Lebret, E., van der Sluijs Jeroen P, van der Sluijs, J.P., Dep IRAS, Petersen, A. K., Knol Anne B, Knol, A.B., Arthur C Petersen, Risk Assessment of Toxic and Immunomodulatory Agents, Jeroen P van der Sluijs, Environmental risk management, Petersen Arthur C, Erik Lebret, Lebret Erik, Anne B Knol, Dep Scheikunde   +15 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Paris targets within reach by aligning, broadening and strengthening net-zero pledges

Communications Earth & Environment
Many countries have recently announced the ambition to reach net-zero emissions targets. Here we explore the climate and energy transition impacts of the following strategies using the IMAGE integrated assessment model: 1) implementing the pledged 2030 ...
Ioannis Dafnomilis, Michel den Elzen, Detlef van Vuuren   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Critical Evaluation of Global Environmental Assessments: The Climate Experience

, 2020
This report is archived online at https://web.archive.org/web/20170704090856/https://www.hks.harvard.edu/gea/pubs/97swr.htm. The publication is no longer available at the URL cited in the original document.
Global Environmental Assessment Project
core   +4 more sources

Hazards of diisobutyl phthalate (DIBP) exposure: A systematic review of animal toxicology studies

Environment International, 2019
Background: Biomonitoring studies indicate a trend towards increased human exposure to diisobutyl phthalate (DIBP), a replacement for dibutyl phthalate (DBP). Recent reviews have found DIBP to be a male reproductive toxicant, but have not evaluated other
Erin E. Yost, Susan Y. Euling, James A. Weaver, Brandiese E.J. Beverly, Nagalakshmi Keshava, Anuradha Mudipalli, Xabier Arzuaga, Todd Blessinger, Laura Dishaw, Andrew Hotchkiss, Susan L. Makris   +10 more
doaj   +1 more source

Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies

Environment International, 2020
Background: Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of ...
James A. Weaver, Brandiese E.J. Beverly, Nagalakshmi Keshava, Anuradha Mudipalli, Xabier Arzuaga, Christine Cai, Andrew K. Hotchkiss, Susan L. Makris, Erin E. Yost   +8 more
doaj   +1 more source

Enhanced phenol removal by permanganate with biogas residue biochar: catalytic role of in-situ formation of manganese dioxide and activation of biochar

Biochar, 2023
Increased biogas residue related to the rapid development of anaerobic fermentation has become an urgent environmental problem. The pyrolysis of biogas residue into biochar is one of the most promising treatments.
Dongyang Li, Yi Xiao, Beidou Xi, Tiancheng Gong, Ting Zhang, Nannan Huang, Wenxuan Li, Tianxue Yang   +7 more
doaj   +1 more source