Results 91 to 100 of about 1,993,735 (313)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

The Determinants of Individuals’ Attitudes Towards Preventing Environmental Damage [PDF]

open access: yes
This paper investigates empirically the determinants of individuals’ attitudes towards preventing environmental damage in Spain using data from the World Values Survey and European Values Survey for the periods 1990, 1995 and 1999/2000.
Benno Torgler, Maria A. Garcia-Valiñas
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Adaptation, internalization and environmental damage [PDF]

open access: yes, 2002
Existing literature ignores adaptation responses to external effects which, in turn, affect the design of appropriate internalization instruments.
Abrego, Lisandro, Whalley, John
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Taking account of environmental damage:a brief overview [PDF]

open access: yes, 2014
Legal systems can take account of environmental damage in different ways. One is to use the existing structures of tort and delict but to recognise new ways in which personal and property interests can be harmed through the loss of ecosystem services, in
Reid, Colin T.
core   +1 more source

Spatial risk measures and applications to max-stable processes

open access: yes, 2016
The risk of extreme environmental events is of great importance for both the authorities and the insurance industry. This paper concerns risk measures in a spatial setting, in order to introduce the spatial features of damages stemming from environmental
Koch, Erwan
core   +1 more source

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