Results 81 to 90 of about 13,473,267 (315)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Heterogeneity, nonlinearity, and multifactor interactions of polycyclic aromatic hydrocarbons in steelworks soils

Environmental Science and Ecotechnology
Industrial polycyclic aromatic hydrocarbons (PAHs) pollution threatens soil ecosystems worldwide, posing persistent risks due to their toxicity and intricate transport dynamics.
Yixuan Hou, Xiaoyong Liao, You Li, Hongying Cao   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Principal component analysis and perturbation theory–based robust damage detection of multifunctional aircraft structure [PDF]

, 2013
A fundamental problem in structural damage detection is to define an efficient feature to calculate a damage index. Furthermore, due to perturbations from various sources, we also need to define a rigorous threshold whose overtaking indicates the ...
HAJRYA, Rafik, MECHBAL, Nazih
core   +1 more source

Remote sensing‐based mapping of structural building damage in the Ahr valley

Journal of Flood Risk Management
Flood damage data are needed for various applications. Structural damage of buildings can reflect not only the economic damage but also the life‐threatening condition of a building, which provide crucial information for disaster response and recovery ...
Guilherme Samprogna Mohor, Tobias Sieg, Oliver Koch, Aaron Buhrmann, Holger Maiwald, Jochen Schwarz, Annegret H. Thieken   +6 more
doaj   +1 more source

Regional differences in health exposure risk of indoor benzene series and safety threshold determination for the Chinese population

Ecotoxicology and Environmental Safety
Indoor benzene series (BTEX) pollution from building and decoration materials poses growing health risks during China's urbanization. Nationwide multi-scenario exposure assessments remain limited, and the risk-based thresholds for benzene and ...
Xuepu Ma, You Li, Xiaoyong Liao, Liang Wang, Huan Tao, Hongying Cao   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

An integrated approach for determining the spatial distribution, source apportionment and human health risks of PAHs in soils of rapidly-urbanized areas

Soil & Environmental Health
The rise of large urban agglomerations has exacerbated pollutant emissions, resulting in regional soil contamination with polycyclic aromatic hydrocarbons (PAHs), which jeopardizes the development of urban agglomerations and affects human health.
Lingzhi Luo, Xiaoyong Liao, Huan Tao, You Li, Liang Wang, Hongying Cao, Yonghua Li, Weiwei Shi, Tianyi Wang   +8 more
doaj   +1 more source