Results 61 to 70 of about 636,730 (266)

Remote sensing‐based mapping of structural building damage in the Ahr valley

open access: yesJournal of Flood Risk Management
Flood damage data are needed for various applications. Structural damage of buildings can reflect not only the economic damage but also the life‐threatening condition of a building, which provide crucial information for disaster response and recovery ...
Guilherme Samprogna Mohor   +6 more
doaj   +1 more source

Regional differences in health exposure risk of indoor benzene series and safety threshold determination for the Chinese population

open access: yesEcotoxicology and Environmental Safety
Indoor benzene series (BTEX) pollution from building and decoration materials poses growing health risks during China's urbanization. Nationwide multi-scenario exposure assessments remain limited, and the risk-based thresholds for benzene and ...
Xuepu Ma   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Inconspicuous Ecocide: Photographs of Environmental Damage Wrought by the Russian Invasion of Ukraine [PDF]

open access: yesKronos
This article is devoted to the problem of photographic representation of the environmental harm caused by the Russian invasion of Ukraine. In many cases, this damage is intentional and due to the military strategy employed by the Russian military.
Denis Skopin
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

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