Results 61 to 70 of about 1,410,058 (263)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

In Search of a Sustainable Global Agri-Food System [PDF]

, 2013
The potential to meet global food demand fully exists through global development of the high-technology (HT), high-intensity type of agriculture and food processing system prevailing in developed countries.
Gooday, Andrew, Gooday, Andrew, KITAZATO, HIROSHI, NOMAKI, HIDETAKA, OGURI, KAZUMASA, TSUCHIYA, MASASHI, 北里, 洋, 土屋, 正史, 小栗, 一将, 野牧, 秀隆   +9 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Heterogeneity, nonlinearity, and multifactor interactions of polycyclic aromatic hydrocarbons in steelworks soils

Environmental Science and Ecotechnology
Industrial polycyclic aromatic hydrocarbons (PAHs) pollution threatens soil ecosystems worldwide, posing persistent risks due to their toxicity and intricate transport dynamics.
Yixuan Hou, Xiaoyong Liao, You Li, Hongying Cao   +3 more
doaj   +1 more source

Aging as a consequence of misrepair -- A novel theory of aging [PDF]

, 2009
It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been
Arne Wunderlin, Jicun Wang, Ravi Mahadeva, Thomas Michelitsch   +3 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An integrated approach for determining the spatial distribution, source apportionment and human health risks of PAHs in soils of rapidly-urbanized areas

Soil & Environmental Health
The rise of large urban agglomerations has exacerbated pollutant emissions, resulting in regional soil contamination with polycyclic aromatic hydrocarbons (PAHs), which jeopardizes the development of urban agglomerations and affects human health.
Lingzhi Luo, Xiaoyong Liao, Huan Tao, You Li, Liang Wang, Hongying Cao, Yonghua Li, Weiwei Shi, Tianyi Wang   +8 more
doaj   +1 more source

On Environmental Taxation under Uncertainty [PDF]

This paper addresses optimal taxation, when the relationship between consumption and environmental damage is uncertain and treated as a random variable by policy makers.
Aronsson, Thomas, Blomquist, Sören
core