Results 61 to 70 of about 1,993,735 (313)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Heterogeneity, nonlinearity, and multifactor interactions of polycyclic aromatic hydrocarbons in steelworks soils

Environmental Science and Ecotechnology
Industrial polycyclic aromatic hydrocarbons (PAHs) pollution threatens soil ecosystems worldwide, posing persistent risks due to their toxicity and intricate transport dynamics.
Yixuan Hou, Xiaoyong Liao, You Li, Hongying Cao   +3 more
doaj   +1 more source

Environmental Law, Governance, and Management- the Need for Environmental Management Systems for Cities [PDF]

, 2012
Human activities damage the environment. They deplete natural resources, generate pollution and wastes, accelerate the loss of forests and biological diversity, as well as threaten the water supply. As populations increase, these problems are exacerbated.
Lin Heng, Lye
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

An integrated approach for determining the spatial distribution, source apportionment and human health risks of PAHs in soils of rapidly-urbanized areas

Soil & Environmental Health
The rise of large urban agglomerations has exacerbated pollutant emissions, resulting in regional soil contamination with polycyclic aromatic hydrocarbons (PAHs), which jeopardizes the development of urban agglomerations and affects human health.
Lingzhi Luo, Xiaoyong Liao, Huan Tao, You Li, Liang Wang, Hongying Cao, Yonghua Li, Weiwei Shi, Tianyi Wang   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Remote sensing‐based mapping of structural building damage in the Ahr valley

Journal of Flood Risk Management
Flood damage data are needed for various applications. Structural damage of buildings can reflect not only the economic damage but also the life‐threatening condition of a building, which provide crucial information for disaster response and recovery ...
Guilherme Samprogna Mohor, Tobias Sieg, Oliver Koch, Aaron Buhrmann, Holger Maiwald, Jochen Schwarz, Annegret H. Thieken   +6 more
doaj   +1 more source

Regional differences in health exposure risk of indoor benzene series and safety threshold determination for the Chinese population

Ecotoxicology and Environmental Safety
Indoor benzene series (BTEX) pollution from building and decoration materials poses growing health risks during China's urbanization. Nationwide multi-scenario exposure assessments remain limited, and the risk-based thresholds for benzene and ...
Xuepu Ma, You Li, Xiaoyong Liao, Liang Wang, Huan Tao, Hongying Cao   +5 more
doaj   +1 more source

On Environmental Taxation under Uncertainty [PDF]

This paper addresses optimal taxation, when the relationship between consumption and environmental damage is uncertain and treated as a random variable by policy makers.
Aronsson, Thomas, Blomquist, Sören
core  

"How much is enough?" Determining adequate levels of environmental compensation for wind power impacts using equivalency analysis [PDF]

, 2009
Environmental considerations at wind power developments require avoidance and mitigation of environmental impacts through proper citing, operational constraints, etc.
Cole, Scott
core