Results 81 to 90 of about 1,993,735 (313)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Debate: Can Sustainable Tourism include Flying? [PDF]

, 2013
Can Sustainable tourism include flying? was the question addressed by the debate at the University of Central Lancashire (University of Central Lancashire), UK on March 30th 2012.
Peeters, Peeters, Scott, Sharpley, Urry
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Inconspicuous Ecocide: Photographs of Environmental Damage Wrought by the Russian Invasion of Ukraine [PDF]

Kronos
This article is devoted to the problem of photographic representation of the environmental harm caused by the Russian invasion of Ukraine. In many cases, this damage is intentional and due to the military strategy employed by the Russian military.
Denis Skopin
doaj   +1 more source

Numerical analysis of mercury transport processes in the Yarly-Amry and Chibitka rivers in the area of the Aktash Mining and Metallurgical Enterprise (Gorny Altay)

Водное хозяйство России: проблемы, технологии, управление, 2023
Mercury pollution of environment relates to the most significant environmental problems of the Republic of Altay. The Aktash mercury deposit area and adjacent production plot of the former mining/metallurgical plant are the most contaminated territory ...
Vladimir F. Raputa, Dmitry V. Yusupov
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Creation of Artificial Aeration System to Improve Water Quality in Reservoirs

Hydrology
Hydroelectric power plants are widely used around the world, particularly in the countries of Central and South America. In Russia, there are more than 15 large hydroelectric power plants, which form the backbone of the country’s energy sector, providing
Artyom F. Khasanov, Anzhelika M. Eremeeva   +1 more
doaj   +1 more source

Reflections on the environmental damage compensation regime in Chinese civil legislations. [PDF]

Heliyon, 2023
Xu Q, Khan MI.
europepmc   +1 more source

International Environmental Agreements in the Presence of Adaptation [PDF]

We show that adaptive measures undertaken by countries in the face of climate change, apart from directly reducing the damage caused by climate change, may also indirectly mitigate greenhouse gas emissions by increasing the stable size of international ...
Amrita Ray Chaudhuri, Walid Marrouch
core