Results 31 to 40 of about 550,045 (257)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Environmental Kuznets Curve Theory on Environmental Degradation in ASEAN-5

Indonesian Interdisciplinary Journal of Sharia Economics
The decline in environmental quality due to increasing greenhouse gas emissions is now a crucial challenge amidst the rapid industrialization of the Southeast Asian region.
Ramadhanti Ramadhanti, Azwardi Azwardi, Muhammad Subardin   +2 more
doaj   +1 more source

Pobreza rural e degradação ambiental: uma refutação da hipótese do círculo vicioso

Revista de Economia e Sociologia Rural, 2004
O estudo analisa as relações entre pobreza rural e degradação ambiental, tendo como área de estudo os municípios de Machadinho e Maximiliano de Almeida, na região Noroeste do RS. Com base nas entrevistas com 48 agricultores, foi formado um banco de dados,
Paulo D. Waquil, Marcus V. A. Finco, Ely J. Mattos   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

CLIMATE CHANGE AND COMMUNITY ENVIRONMENTAL CONFLICTS: ARE THEY CORRELATED?

Sriwijaya Law Review, 2017
Climate change and global warming affect major change in freshwater availability and season uncertainty which hamper all part of the globe. Although the phenomenon is not new but it needs concerns from all the government of States around the world to ...
Achmad Romsan, Farida Ali, Akhmad Idris, Adrian Nugraha, Nurhidayatuloh Nurhidayatuloh, Suzanna Mohamed Isa   +5 more
doaj   +1 more source

Addressing Climate Change Vulnerability in the IUCN Red List of Ecosystems—Results Demonstrated for a Cross-Section of Major Vegetation-Based Ecosystem Types in the United States

Land, 2022
The IUCN Red List of Ecosystems (RLE) is a global standard for ecosystem risk assessment that integrates data and knowledge to document the relative risk status of ecosystem types as critically endangered (CR), endangered (EN), and vulnerable (VU).
Patrick J. Comer, Jon C. Hak, Patrick McIntyre   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Impact of Environmental Technologies and Environmental Policy Stringency on Environmental Degradation

Ekonomi, Politika & Finans Araştırmaları Dergisi
The increase in global warming and environmental pollution accelerates ecological degradation and prompts governments worldwide to adopt policies aimed at addressing environmental challenges while maintaining economic growth.
Özen Akçakanat, Gökhan Özkul, Ozan Özdemir, Muhammed Kasım   +3 more
doaj   +1 more source

Effects of financial development, FDI and good governance on environmental degradation in the Arab nation: Dose technological innovation matters?

Frontiers in Environmental Science, 2023
The motivation of the study is to gauge the impact of financial development, FDI, Technological innovation, and good governance on environmental degradation in the Arab Nation for the period 1991–2019. Several techniques have implemented, including error
Shuwen Ju, Anselme Andriamahery, Md Qamruzzaman, Sylvia Kor   +3 more
doaj   +1 more source