Results 41 to 50 of about 550,045 (257)

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Trade and Deforestation Predict Rat Lungworm Disease, an Invasive-Driven Zoonosis, at Global and Regional Scales

open access: yesFrontiers in Public Health, 2021
The introduction of non-native species and deforestation are both important drivers of environmental change that can also facilitate the geographic spread of zoonotic pathogens and increase disease risk in humans. With ongoing trends in globalization and
Luz A. de Wit   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Regulation as a policy contest: the probability of conservation of a renewable resource [PDF]

open access: yesEnvironmental Economics, 2017
How do the levels of extreme positions of various interest groups influence the conservation policies in the context of a renewable resource conservation contest?
Urs Steiner Brandt
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Dynamics of FDI, Technological Transformation and Environmental Degradation in Developing Countries: A Panel Analysis

open access: yesRomanian Economic Journal, 2016
This paper examines the relationship between FDI, technology and environment with an assessment of aggregated relationship, by technical composition and the mode of technology transferability through FDI. A panel data for 19 developing countries has been
Farwa Amjad , Bilal Mehmood
doaj  

Impactos ambientais do manejo agroecológico da caatinga no Rio Grande do Norte Environmental impacts of caatinga agroecological handling in Rio Grande do Norte, Brazil

open access: yesPesquisa Agropecuária Brasileira, 2010
O objetivo deste trabalho foi avaliar os impactos ambientais do manejo agroecológico da caatinga, em unidades de produção familiar no Rio Grande do Norte, pelo método Ambitec de produção animal - dimensão ambiental, desenvolvido pela Embrapa Meio ...
Hilton Felipe Marinho Barreto   +4 more
doaj   +1 more source

Urbanisation and Environmental Degradation in Pakistan [PDF]

open access: yesThe Pakistan Development Review, 1993
The concern over the environment is not new. But the development policymakers have recently recognised that failing to take the costs of environmental damage into account will slow down the process of raising incomes and the wellbeing of the people.
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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