Results 41 to 50 of about 491,354 (237)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Livestock and grassland interrelationship along five centuries of ranching the semiarid grasslands on the southern highlands of the Mexican Plateau

Elementa: Science of the Anthropocene, 2020
Native grasslands worldwide have been degraded by grazing, but the processes involved have been studied insufficiently. Grasslands were a major habitat on the southern section of the Mexican Plateau when the Spaniards arrived 500 years ago.
Eric Mellink, Mónica E. Riojas-López
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dynamics of FDI, Technological Transformation and Environmental Degradation in Developing Countries: A Panel Analysis

Romanian Economic Journal, 2016
This paper examines the relationship between FDI, technology and environment with an assessment of aggregated relationship, by technical composition and the mode of technology transferability through FDI. A panel data for 19 developing countries has been
Farwa Amjad , Bilal Mehmood
doaj  

Pobreza rural e degradação ambiental: uma refutação da hipótese do círculo vicioso

Revista de Economia e Sociologia Rural, 2004
O estudo analisa as relações entre pobreza rural e degradação ambiental, tendo como área de estudo os municípios de Machadinho e Maximiliano de Almeida, na região Noroeste do RS. Com base nas entrevistas com 48 agricultores, foi formado um banco de dados,
Paulo D. Waquil, Marcus V. A. Finco, Ely J. Mattos   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CLIMATE CHANGE AND COMMUNITY ENVIRONMENTAL CONFLICTS: ARE THEY CORRELATED?

Sriwijaya Law Review, 2017
Climate change and global warming affect major change in freshwater availability and season uncertainty which hamper all part of the globe. Although the phenomenon is not new but it needs concerns from all the government of States around the world to ...
Achmad Romsan, Farida Ali, Akhmad Idris, Adrian Nugraha, Nurhidayatuloh Nurhidayatuloh, Suzanna Mohamed Isa   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An activity of the oil industry and its effects on vegetation coverage in the Amazonas state-Brazil.

Revista Técnica de la Facultad de Ingeniería, 2013
The objective of this research is to identify effects in vegetation coverage generated by the activity of the oil industry, and obtain the index of environmental degradation for eight counties of the state of Amazonas-Brazil: Coari, Codajás, Anori, Anam
Marelis Ruiz, Sandra do Nascimento Noda, Eliezer da Silva, Bruno Ladeira, Janiffe Peres de Oliveira   +4 more
doaj  

Do Environmental Tax and Energy Matter for Environmental Degradation in the UK? Evidence from Novel Fourier-Based Estimators

Energies
Currently, the UK has ambitious plans to reach net zero by 2050, despite other countries such as Russia and India targeting 2060 and 2070, respectively.
Kwaku Addai, Souha Hanna Al Geitany, Seyed Alireza Athari, Panteha Farmanesh, Dervis Kirikkaleli, Chafic Saliba   +5 more
doaj   +1 more source