Results 71 to 80 of about 1,526,678 (287)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Biological Agents of Bioremediation: A Concise Review [PDF]
, 2015 Due to intensive agriculture, rapid industrialization and anthropogenic activities have caused environmental pollution, land degradation and increased pressure on the natural resources and contributing to their adulteration.
Biswas, Karabi
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Experimenting with the design of policies on sustainable resources management : Phase 1 final report, January 2004 - February 2005 [PDF]
, 2005 The overall objective of the DMP is to arrest land degradation in Africa's desert margins through demonstration and capacity building activities. The GEF increment to this project will enable the programme to address issues of global environmental ...
Leclerc, Grégoire
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Environmental degradation of claystones
Géotechnique, 2014 The paper presents the results of a comprehensive experimental programme carried out to study the effects of relative humidity cycling on the degradation of argillaceous rocks. Lilla claystone, a low-porosity Tertiary rock, was used for this purpose.
Pineda, J. A., Alonso, E. E., Romero, E.
openaire +2 more sources
Inequality as a Cause of Environmental Degradation [PDF]
This paper advances two hypotheses. First, the extent of an environmentally degrading economic activity is a function of the balance of power between the winners, who derive net benefits from the activity, and the losers, who bear net costs.
James Boyce
core
Experimenting with the design of policies on sustainable resource management : Progress report, June 4, 2004 [PDF]
, 2004 The overall objective of the DMP is to arrest land degradation in Africa's desert margins through demonstration and capacity building activities. The GEF increment to this project will enable the programme to address issues of global environmental ...
Leclerc, Grégoire
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source