Results 61 to 70 of about 539,569 (264)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Scientific Reports, 2022 The effects of organic amendments on the phytoremediation of cadmium (Cd) in acacia (Acacia mangium), jatropha (Jatropha curcas), and cassava (Manihot esculenta) were investigated. The bone meal/bat manure and leonardite/bat manure amendments resulted in
Puntaree Taeprayoon +2 more
doaj +1 more source
Hardware System for Environmental Diagnosis of Air Pollution
Journal of the Russian Universities. Radioelectronics, 2020 Introduction. The existing scientific and technical problem was shown that, on the one hand, in accordance with legislation and international obligations (for example, under the Aarhus Convention), the population can request data on the current state of the environment, and on the other, monitoring systems existing today unable to timely ensure their ...
V. A. Rybak, O. P. Ryabychina
openaire +3 more sources
Environmental pollutants and human diseases: diagnosis and treatment [PDF]
WIT Transactions on Biomedicine and Health, 2005 Environmental factors play a central role in the processes of human development, health, and disease. Human exposure to hazardous agents in the air, water, soil, and food and to physical hazards in the environment is a major contributor to increased morbidity and mortality.
Passerini, G. +2 more
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Melanogenesis and MITF expression in primary melanomas: an immunohistochemical study
Surgical and Experimental PathologyBackground The Microphthalmia-associated transcription factor - MITF is a key regulator of melanogenesis, controlling melanin production and pigment phenotype in melanocytes. It also influences cell differentiation, proliferation, and survival.
Karina Munhoz de Paula Alves Coelho +5 more
doaj +1 more source