Results 101 to 110 of about 22,349,223 (341)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Environmental Education and Educational Quality and Relevance-Opening the debate [PDF]

open access: yes, 2008
This edition of the Southern African Journal of Environmental Education (SAJEE) tackles a critical issue being debated across the world today, namely the question of educational quality and relevance.
Lotz-Sisitka, Heila
core  

ENVIRONMENTAL EDUCATION IN ISRAEL

open access: yesStudia Universitatis Moldaviae: Stiinte ale Educatiei, 2014
It is recognized worldwide that the Environmental Education is part of a national strategy for guarding the quality of life and environment. In the last few years, too many efforts and budgets were invested to develop Environmental Edu- cation programs ...
USM ADMIN
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

1999 Environmental Education Grant Profiles [PDF]

open access: yes, 1999
66 pages; available for download at the link below.This report summarizes 206 environmental education grants awarded by the U.S. Environmental Protection Agency (EPA) during fiscal year (FY) 1999.
United States Environmental Protection Agency Office of Communications, Education, and Media Relations
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Education for sustainable development through the Foundation for Environmental Education : Eco-Schools, Learning about Forests & Young Reporters for the Environment

open access: yes, 2020
Information booklet for International Schools Foundation for Environmental Education (FEE). Content: About the Eco-Schools programme -- About the LEAF programme -- Implementing the LEAF programme -- About the YRE programme -- The YRE programme offers ...
Foundation for Environmental Education (FEE)
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ENVIRONMENTAL EDUCATION AND TEACHING METHOD OF ENVIRONMENTAL EDUCATION

open access: yes, 2015
In the post-independence era, urbanization in the wake of large-scale industrialization has brought about wide spread environmental degradation. Industries sprang up all over Gujarat in the sixties in an unplanned fashion which uprooted hundreds of small and marginal framers following land acquisition.
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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