Results 81 to 90 of about 12,174,591 (329)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Qualitative Research in Education, 2020 The aim of this research is to improve environmental awareness in primary school students. For this purpose, the study was carried out within the scope of action research pattern from qualitative research patterns.
Mustafa Yeşilyurt +2 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
ENVIRONMENTAL EDUCATION IN ISRAEL
Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2014 It is recognized worldwide that the Environmental Education is part of a national strategy for guarding the quality of life and environment. In the last few years, too many efforts and budgets were invested to develop Environmental Edu- cation programs ...
USM ADMIN
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Rapid assessment protocols of rivers as instruments of environmental education in elementary schools
Revista Ambiente & Água, 2017 The aim of the present study is to assess the use of rapid assessment protocols (RAPs) of rivers as environmental education (EE) instruments in elementary schools.
Ariane Guimarães +2 more
doaj +1 more source
Mapping Child Well-Being in Duval County, FL [PDF]
, 2011 Analyzes the distribution of neighborhood, education, and health/environmental opportunity; impact on health and education outcomes; demographics of those in Children's Commission programs; and marginalized neighborhoods' conditions.
Mikyung Baek +2 more
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Environmental Education and Student’s Perception, for Sustainability
Sustainability, 2019 Environmental education and education for the environment today play an important role toward sustainability. Environmental education provided by higher education institutions has an important impact on training and preparing the future generation for a ...
G. Boca, Sinan Saraçlı
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source