Results 91 to 100 of about 5,408,281 (241)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Novel Method for Single-Station Lightning Distance Estimation Based on the Physical Time Reversal

Remote Sensing
A single-station lightning location has the obvious advantages of low cost and convenience in lightning monitoring and warning. To address the critical challenge of distance estimation accuracy in this technology, we propose a novel physical time ...
Yingcheng Zhao, Zheng Sun, Yantao Duan, Hailin Chen, Yicheng Liu, Lihua Shi   +5 more
doaj   +1 more source

Design Dual-Polarization Frequency Selective Rasorber Using Split Ring Resonators

IEEE Access, 2019
A novel dual-polarization frequency selective rasorber with one transmission band and two absorbing bands is proposed in this paper. The structure is composed of a lossless frequency selective surface layer and a resistive layer. The resistive layer is a
Ximeng Zhang, Weiwei Wu, Yuhong Ma, Chang Wang, Chenxin Li, Naichang Yuan   +5 more
doaj   +1 more source

Environmental effects on polymeric matrix composites [PDF]

Current epoxy resins utilized in high performance structural composites absorb moisture from high humidity environments. Such moisture absorption causes plasticization of the resin to occur with concurrent swelling and lowering of the glass transition ...
Husman, G. E., Whitney, J. M.
core   +1 more source

A Modelling Approach for Evaluating Agri-Environmental Policies at Sector Level [PDF]

, 2008
This paper presents a new approach to evaluate the cost effectiveness of agri-environmental policies at sector level. Policy uptake, cumulative environmental effects and public expenditure are identified as the main determinants of cost-effectiveness. On
Lampkin, N. H., Nemecek, T, Sanders, J., Schader, C., Stolze, M.   +4 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Active substrate integrated terahertz waveguide using periodic graphene stack

AIP Advances, 2015
The transmission properties of a substrate integrated waveguide (SIW) based on periodic graphene stacks have been theoretically investigated in the terahertz (THz) region.
Yanfei Dong, Peiguo Liu, Dingwang Yu, Bo Yi, Gaosheng Li   +4 more
doaj   +1 more source

Environmental Effects of Watershed Modifications [PDF]

Watershed management is more effective when there is a relief from the population to exploit the land. Undoubtedly, such policies must be premised on a full appreciation of the interdependence and the extent of interaction of the various components of ...
David, Wilfredo P.
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source