Results 81 to 90 of about 15,581,855 (303)

National Environmental Public Health Tracking Program strategic plan : fiscal years 2016 \u2013 2020 [PDF]

For more than a decade, the Environmental Public Health Tracking Program (\u201cTracking Program\u201d) has collected, integrated, and analyzed non-infectious disease and environmental data from a nationwide network of partners.

core  

A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF

Nature Communications
To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus CTGF could be an
Cao Lu, Cong Meng, Yuying Li, Jinling Yuan, Xiaojun Ren, Liang Gao, Dongdong Su, Kai Cao, Mengchao Cui, Qing Yuan, Xueyun Gao   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Novel Method for Single-Station Lightning Distance Estimation Based on the Physical Time Reversal

Remote Sensing
A single-station lightning location has the obvious advantages of low cost and convenience in lightning monitoring and warning. To address the critical challenge of distance estimation accuracy in this technology, we propose a novel physical time ...
Yingcheng Zhao, Zheng Sun, Yantao Duan, Hailin Chen, Yicheng Liu, Lihua Shi   +5 more
doaj   +1 more source

Design Dual-Polarization Frequency Selective Rasorber Using Split Ring Resonators

IEEE Access, 2019
A novel dual-polarization frequency selective rasorber with one transmission band and two absorbing bands is proposed in this paper. The structure is composed of a lossless frequency selective surface layer and a resistive layer. The resistive layer is a
Ximeng Zhang, Weiwei Wu, Yuhong Ma, Chang Wang, Chenxin Li, Naichang Yuan   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Six Distributional Effects of Environmental Policy [PDF]

While prior literature has identified various effects of environmental policy, this note uses the example of a proposed carbon permit system to illustrate and discuss six different types of distributional effects: (1) higher prices of carbon-intensive ...
Don Fullerton
core   +2 more sources

Active substrate integrated terahertz waveguide using periodic graphene stack

AIP Advances, 2015
The transmission properties of a substrate integrated waveguide (SIW) based on periodic graphene stacks have been theoretically investigated in the terahertz (THz) region.
Yanfei Dong, Peiguo Liu, Dingwang Yu, Bo Yi, Gaosheng Li   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source