Results 151 to 160 of about 8,455,634 (356)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Web-Based Roadway Geometry Design Software for Transportation Education [PDF]

open access: yes
Traditionally, students use pencil and ruler to lay out lines and curves over contour maps for roadway geometry design. Numerous calculations of stopping sight distance, minimum turning radius, and curve alignments are required during the roadway design ...
Chen-Fu Liao, David Levinson
core  

Waterworks Sludge: An Underrated Material for Beneficial Reuse in Water and Environmental Engineering

open access: yesWaste and Biomass Valorization, 2020
Yaqian Zhao   +6 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Life Cycle Carbon Emissions of GSHP Versus Traditional HVAC System for Residential Building: A Case from Jinan, China

open access: yesBuildings
The building sector represents a major source of global carbon emissions, with heating and cooling systems being particularly critical contributors, making the evaluation of sustainable low-carbon alternatives an urgent priority.
Jiayi Wang   +5 more
doaj   +1 more source

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