Results 51 to 60 of about 6,076,005 (293)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Operant Methodology Out Of The Lab and Applied To Enrichment With Captive Chimpanzees (Pan Troglodytes) [PDF]
, 2008 A group of socially-housed chimpanzees, maintained in a zoo facility, were given the opportunity to access each of several purpose-designed and built enrichment items.
Vivian, Melanie
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
ELEMENTS FOR ENVIRONMENTAL ENRICHMENT FOR PREGNANT SOWS
Tropical and Subtropical AgroecosystemsBackground: Animal welfare largely depends on their ability to cope with their environment. Absence has a negative impact on the health of animals and, consequently, on the profitability of a farm.
Guadalupe Espejo Beristain +5 more
doaj +1 more source
Environmental Enrichment for Broiler Breeders: An Undeveloped Field
Frontiers in Veterinary Science, 2017 Welfare problems, such as hunger, frustration, aggression, and abnormal sexual behavior, are commonly found in broiler breeder production. To prevent or reduce these welfare problems, it has been suggested to provide stimulating enriched environments. We
Anja B. Riber +3 more
doaj +1 more source
The importance of burrowing, climbing and standing upright for laboratory rats [PDF]
Royal Society Open Science, 2016 Standard laboratory cages prevent rats (Rattus norvegicus) from performing many behaviours that they perform in the wild, but little is known about how this may affect their welfare.
I. Joanna Makowska, Daniel M. Weary
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Environmental enrichment for big cats
, 2002 This project addresses environmental enrichment for the big cats in the Southwick Zoo. Environmental enrichment is giving the animal back as much control over its life as captivity will allow, promoting the psychological well being of captive animals by ...
Varhegyi, Kira P., Dewilde, Abiche Helen
core +2 more sources