Results 71 to 80 of about 307,568 (302)
Environmental-based enrichment - Humboldt penguin (Spheniscus humboldti) [PDF]
, 2022 Increased activity in the pool environment is, according to previous studies on similar aquatic birds, a clear indicator of good welfare. The welfare of animals in captivity is something many researchers and animal keepers are constantly striving to ...
Silwer, Amanda
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Environmental enrichment to improve swine survivability
, 2022 The United States swine industry has made survivability a top priority across all production phases. Mortality and morbidity hinder pig survivability and in turn this detrimentally affects performance, economic return, and pig welfare.
Sundman, Emiline Renee
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Environmental enrichment: a GAP analysis
, 2007 GAP analyses are tools used to inform us about the short-comings of a scientific area or necessities in social–economic problems. In the last 20 years, environmental enrichment as an area of scientific investigation has come of age; this can be clearly ...
Young, R, de Azevedo, C, Cipreste, C
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2021 Nurse sharks (Ginglymostoma cirratum, Ginglymostomatidae) are one of the most exhibited shark species in aquariums worldwide. However, in these locations, their reproductive success rate is frequently low.
Gadig, Otto Bismarck Fazzano [UNESP] +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2008 A group of socially-housed chimpanzees, maintained in a zoo facility, were given the opportunity to access each of several purpose-designed and built enrichment items.
Vivian, Melanie
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source