Results 71 to 80 of about 6,076,005 (293)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Environmental enrichment remodels brain structural and behavioral plasticity in restricted and repetitive C58 mouse models

NeuroImage
Restricted and repetitive behaviors are characteristic of several neurodevelopmental disorders, particularly autism spectrum disorder. While environmental enrichment has been shown to affect these behaviors, the underlying neural mechanisms remain poorly
Qiang Li, Anna L. Farmer, Godfrey D. Pearlson, Vince D. Calhoun   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

Neurobiology of Disease, 2016
Introduction: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on epilepsy development and severity, and whether this influence is transmitted to subsequent generations, is not well known ...
Gabi Dezsi, Ezgi Ozturk, Michael R. Salzberg, Margaret Morris, Terence J. O'Brien, Nigel C. Jones   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: Enriched environments normally increase behavioral repertoires and diminish the expression of abnormal behaviors and stress-related physiological problems in animals.
Déborah Maria Moreira da Silva, Laila Pinheiro, Cristiano Schetini Azevedo, Guilherme de Paula Costa, André Talvani   +4 more
doaj   +1 more source

Pig’s behavioral response in nursery and growth phases to environmental enrichment objects

Spanish Journal of Agricultural Research, 2018
The objective of this research was to evaluate the effect of environmental enrichment on the behavior of pigs in nursery and growth phases. (i) Ninety animals (females, 65 days, 25 kg) were divided into three treatments (T1- Pen enriched with objects ...
Luciana Foppa, Fabiana R. Caldara, Rafael de Moura, Simone P. Machado, Irenilza A. Nääs, Rodrigo G. Garcia, Liliane M. P. Gonçalves, Geyssane F. de Oliveira   +7 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source