Results 61 to 70 of about 307,568 (302)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Restricted Daily Exposure of Environmental Enrichment: Bridging the Practical Gap from Animal Studies to Human Application [PDF]

Daily restricted environmental enrichment (REE) refers to limited, structured periods of enrichment aimed at improving both physical and cognitive well-being in animals and humans.
Aswir Abd Rashed, Nasarudin, Siti Nur Atiqah Zulaikah, Ramasamy, Rajesh, Rajesh Ramasamy, Abdul Mutalib, Maisarah, Maisarah Abdul Mutalib, Siti Nur Atiqah Zulaikah Nasarudin, Nik Ramli, Nik Nasihah, Abd Rashed, Aswir, Kamarul Sahrin, Nurin Amalia, Mohamad Alwi, Muhammad Najib, Nik Nasihah Nik Ramli, Muhammad Najib Mohamad Alwi, Hashim, Mohamad Hisham, Mohamad Hisham Hashim, Nurin Amalia Kamarul Sahrin   +15 more
core   +1 more source

The impact of environmental enrichment on the outcome variability and scientific validity of laboratory animal studies. [PDF]

, 2014
It has been widely accepted for some time that species-appropriate environmental enrichment is important for the welfare of research animals, but its impact on research data initially received little attention.
Bayne, K., Würbel, H.
core   +1 more source

Goal-oriented behavioural and environmental enrichment in aquarium species [PDF]

, 2021
Environmental enrichment is a common tool used in zoo and aquarium settings to provide mental and physical stimulation to animals under human care. This paper aims to present a primary approach to goal-oriented environmental and behavioural enrichment ...
Manteca Vilanova, Xavier, Vaicekauskaite, Ruta, Palencia Membrive, Gemma, Delfour, Fabienne, Monreal-Pawlowsky, Tania   +4 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Impact of different housing densities combined with Environmental enrichment on the production of Japanese quail

Acta Scientiarum: Animal Sciences
This study evaluated the zootechnical performance, egg quality, and behavior of Japanese quails in the laying phase housed in cages of different densities and with or without environmental enrichment.
Marcílio José Vieira, Michele de Oliveira Mendonça, Jean Kaique Valentim, Damares de Castro Fidélis, Steferson dos Reis Oliveira, Samuel Oliveira Borges   +5 more
doaj   +1 more source

Environmental enrichment modulates cortico-cortical interactions in the mouse.

PLoS ONE, 2011
Environmental enrichment (EE) is an experimental protocol based on a complex sensorimotor stimulation that dramatically affects brain development. While it is widely believed that the effects of EE result from the unique combination of different sensory ...
Angelo Di Garbo, Marco Mainardi, Santi Chillemi, Lamberto Maffei, Matteo Caleo   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

REPRODUCTIVE EFFICIENCY AND BEHAVIOR OF PREGNANT SOWS HOUSED IN CAGES AND COLLECTIVE PENS WITH OR WITHOUT BEDDING [PDF]

Engenharia Agrícola
This study aimed to evaluate the effect of wood shaving bedding on pregnant sows under two housing conditions. Sixty-four animals were distributed into four treatments, each treatment included 54 sows split into three replicates. A 2 × 2 factorial design
Maria L. A. N. Zotti, Késia O. da S. Miranda, Afrânio M. C. Vieira, Joana B. Demsk, Gislaine G. Romano   +4 more
doaj   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source