Results 61 to 70 of about 260,132 (290)

REPRODUCTIVE EFFICIENCY AND BEHAVIOR OF PREGNANT SOWS HOUSED IN CAGES AND COLLECTIVE PENS WITH OR WITHOUT BEDDING [PDF]

Engenharia Agrícola
This study aimed to evaluate the effect of wood shaving bedding on pregnant sows under two housing conditions. Sixty-four animals were distributed into four treatments, each treatment included 54 sows split into three replicates. A 2 × 2 factorial design
Maria L. A. N. Zotti, Késia O. da S. Miranda, Afrânio M. C. Vieira, Joana B. Demsk, Gislaine G. Romano   +4 more
doaj   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice

Neural Regeneration Research, 2019
Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on synaptic remodeling in a mouse model of ...
Chuan-Jie Wang, Yi Wu, Qun Zhang, Ke-Wei Yu, Yu-Yang Wang   +4 more
doaj   +1 more source

Effects of Intermittent Exercise during Initial Rainbow Trout Oncorhynchus mykiss Rearing in Tanks Containing Vertically-Suspended Environmental Enrichment [PDF]

, 2020
Benj Morris, Jill M. Voorhees, Nathan Huysman, Eric Krebs, Michael E. Barnes, South, X Li, L Yu, C Wang, L Zeng, Z Cao, G Liu, Y Wu, X Qin, X Shi, X Wang, M Martin-Perez, J Fernandez-Borras, A Ibarz, A Millan-Cubillo, O Felip, J Shrivastava, B Rakovi, R Blust, De Boeck, G, B Gerber, A Stamer, T Stadtlander, J Christiansen, E Ring, M Jobling, T Gregory, C Wood, D Houlihan, P Laurent, J Lagasse, D Leith, D Romey, O Dahrens, J Voorhees, M Barnes, S Chipps, M Brown, S Reiser, N Shn, D Pohlmann, M Willenberg, U Focken, J Christiansen, M Jobling, W Davison, G Goldspink, E Brown, M Bruce, S Pether, N Herbert, J Voorhees, M Barnes, S Chipps, M Brown, J Voorhees, N Huysman, E Krebs, M Barnes, T Bosakowski, E Wagner, B Berejikian, E Tezak, T Flagg, A Larae, E Kummerow, B Berejikian, J Nslund, M Rosengren, Del Villar, D Gansel, L Norrgard, J, Agv Salvanes, O Moberg, Loe Ebberson, T Nilsen, K Jensen, L Roberts, J Taylor, P Gough, D Forman, C Leaniz, I Bergendahl, Agv Salvanes, V Braithwaite, K Cogliati, C Herron, Dlg Noakes, C Schreck, J Kientz, M Barnes, J Kientz, K Crank   +99 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Environmental enrichment reduces adolescent anxiety- and depression-like behaviors of rats subjected to infant nerve injury

Journal of Neuroinflammation, 2018
Background Infant nerve injury causes delayed adolescent neuropathic pain, but whether it also leads to psychiatric illness is unknown. Environmental enrichment (EE) increases social communication and activity.
Xingrui Gong, Yongmei Chen, Jing Chang, Yue Huang, Meihau Cai, Mazhong Zhang   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source