Results 71 to 80 of about 4,559,142 (274)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Where has all the $r$-process gone? Timescales for GRB-Kilonovae to Enrich their Host Galaxies [PDF]

open access: yes
Neutron star (NS) mergers are currently the only observed source of $r$-process production in the Universe. Yet, it is unclear how much $r$-process mass from these mergers is incorporated into star-forming gas to enrich stars. This is crucial to consider as all other $r$-process mass estimates in the Universe beyond Earth are based on stellar $r ...
arxiv   +1 more source

Search for a metallicity spread in the multiple population Large Magellanic Cloud cluster NGC 1978 [PDF]

open access: yes, 2018
We report on the spread of [Fe/H] values in the massive Large Magellanic Cloud cluster NGC1978, recently confirmed to harbor multiple populations of nearly the same age. We used accurate Stromgren photometry of carefully selected cluster red giant branch stars along with a high-dispersion spectroscopy-based calibration of the metallicity-sensitive ...
arxiv   +1 more source

Effects of environmental enrichment on survivorship, growth, sex ratio and behaviour in laboratory maintained zebrafish Danio rerio.

open access: yesJournal of Fish Biology, 2018
Environmental enrichment involves increasing the complexity of a fish's environment in order to improve welfare. Researchers are legally obliged to consider the welfare of laboratory animals and poor welfare may result in less robust data in experimental
Carole J Lee, G. Paull, C. Tyler
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice

open access: yesCNS Neuroscience & Therapeutics, 2018
Environmental enrichment (EE) has been shown to enhance cognitive function in mouse models of Alzheimer's disease (AD). Magnesium‐L‐threonate (MgT) is a compound with a newly discovered effect to rescue learning and memory function in aging and AD mice.
Ying Huang   +6 more
semanticscholar   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

open access: yesMolecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan   +6 more
wiley   +1 more source

Enhancing their quality of life: environmental enrichment for poultry

open access: yesPoultry Science, 2022
L. Jacobs   +8 more
semanticscholar   +1 more source

The effect of environmental enrichment on behavioral variability depends on genotype, behavior, and type of enrichment

open access: yesJournal of Experimental Biology, 2019
Non-genetic individuality in behavior, also termed intragenotypic variability, has been observed across many different organisms. A potential cause of intragenotypic variability is sensitivity to minute environmental differences during development, which
Jamilla Akhund-Zade   +3 more
semanticscholar   +1 more source

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