Results 41 to 50 of about 611,538 (299)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Environmental science and environmental ethics [PDF]

open access: yes, 2000
Science and conscience have a complex, elusive relationship and this is nowhere better illustrated than in the relationship between environmental science and environmental ethics.
Oregon State Unviersity, Department of Philosophy, publisher   +1 more
core  

On the demarcation problem and the possibility of environmental ethics : a refutation of "A refutation of environmental ethics"

open access: yes, 2010
According to a popular critique of environmental ethics, the view that nature has intrinsic value faces an insurmountable demarcation problem. This critique was delivered in a particularly forceful manner two decades ago by Janna Thompson in her paper “A
Samuelsson, Lars,, Samuelsson, Lars
core   +1 more source

Nature and culture in environmental ethics [PDF]

open access: yes, 1999
Includes bibliographical references (page [158]).Humans in their cultures are out of sustainable relationships to the natural environments on which these cultures are superimposed.
Philosophy Documentation Center, publisher   +2 more
core   +1 more source

BUSINESS ETHICS AND ENVIRONMENTAL PROBLEMS [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
In this paper researches a role of business ethics in the environment protection, along with respect of the sustainable development modern concept.
Branko MIHAILOVIC, Drago CVIJANOVIC
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Environmental Ethics as Ethics of the Political State

open access: yesProblemy Ekorozwoju, 2016
The main aim of this article is to prove the existence of the need to develop the theory of environmental ethics for the purposes of political activity. Its arguments refer to the following five observation.
Andrzej Papuziński
doaj  

Human Rights and Environmental Ethics [PDF]

open access: yesحقوق بشر, 2010
Happiness of human beings in his/her worldly life and even the hereafter has direct contact with the environment’s health. Healthy environment is central to the worldly and spiritual human prosperity.
Mohammad Ali Basir, Davood Najafi
doaj  

The Ethics of Survival: Responsibility and Sacrifice in Environmental Ethics

open access: yesPhenomenology & Practice, 2013
The primary concern of environmental ethics pushed to the limit is the question of survival. An ethic of survival would concern the possibility of morality in an environmental crisis that promises humanity immeasurable damage, suffering, and even the ...
Ilan Safit
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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