Results 61 to 70 of about 6,208,898 (291)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Interdisciplinary Foundations for Environmental and Sustainability Ethics: An Introduction
Ethics in Progress, 2014 This article introduces the special issue for Ethics in Progress entitled Environment, ethics, and sustainability: Crossroads of our future. Despite four decades of intense development in the field of academic and professional environmental ethics ...
Małgorzata Dereniowska, Jason Matzke
doaj +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
VertigO, 2020 This article investigates new convergences between animal ethics and environmental ethics by focusing on the effects as well as the causes of climate change.
Michel Bourban , Lisa Broussois
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
A Brief History of Enviroethics and Its Challenges [PDF]
Journal of Medical Ethics and History of Medicine, 2009 Environmental ethics has emerged during the early 1970s, when environmentalists started urging philosophers to consider the philosophical aspects of environmental problems. Environmental ethics considers the ethical relationships between humanity and non-
Marjan Laal
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Uma Ética Holística para as Gerações Futuras: caminho para o Novo Direito Ambiental
Revista Interdisciplinar de Direito, 2016 This article discusses the relevance to investigate the concerns based on ethics and on environmental law, with a view to defend and preserve the environment for current and future generations as possible, because it is a right that link ...
Mária de Fátima Alves São Pedro
doaj +3 more sources
Challenges in environmental ethics [PDF]
, 1998 Environmental ethics is an invitation to moral development. Respect for human life is only a subset of respect for all life. What ethics is about is seeing outside your own sector of self-interest, of class interest.
Prentice-Hall, publisher +1 more
core