Results 71 to 80 of about 5,061,490 (331)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

African Environmental Ethics and Sustainable Development

Open Journal of Philosophy, 2019
In this paper, I argue that African environmental ethics can contribute to sustainable development as well as mitigate the devastating effects of global warming and climate change in Africa.
Mbih Jerome Tosam
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Environmental Ethics

Dictionary of Geotourism, 2019
Environmental ethics is an area that investigates the question of which ethical norms are appropriate for governing human interactions with the natural environment. Considered a branch of applied or practical ethics, environmental ethics has only existed
Mfonobong David Udoudom, Okpe Okpe, Timothy Adie, S. A. Bassey   +3 more
semanticscholar   +2 more sources

How Big Data Analytics Capability Promotes Green Radical Innovation? The Effect of Corporate Environment Ethics in Digital Era

Systems
In the digital economy era, firms pursue innovation while also considering their environmental impact to ensure alignment with sustainability. However, existing research offers limited insights into how corporate environmental ethics influence the ...
Weiwei Wu, Xue Li, Guowei Ruan
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Epilogue [PDF]

, 2009
The Environmental Responsibility Reader is a definitive collection of classic and contemporary environmental works that offers a comprehensive overview of the issues involved in environmental responsibility, steering the reader through each development ...
Blackmore, Chris, Reynolds, Martin, Smith, Mark   +2 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

African Environmental Ethics

The International Library of Environmental, Agricultural and Food Ethics, 2019
For decades now, experts have studied and documented the severe environmental and land degradation across Africa. However, the nature of the problem has now been ratcheted up by mounting and undisputed scientific evidence demonstrating a clear causal ...
J. Ogar, S. A. Bassey
semanticscholar   +1 more source

Logical and Theoretical Foundations of African Environmental Ethics [PDF]

, 2016
[English] The paper observed that the various ethics that constitute the system of African environmental ethics are not based on or linked to any known African ontology and formal logic.
Ibanga, Diana-Abasi
core