Results 81 to 90 of about 5,198,168 (326)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Plant Tour and Meeting with Members of Interface’s Sustainability Team: December 16, 2009 [PDF]

open access: yes, 2012
Simply stated, business does not work without the infusion of ethics. While “ethics” can be interpreted in a relative manner, there is no dispute within the scientific community as to the deleterious effects of unrestricted manufacturing processes and ...

core   +1 more source

Development Ethics [PDF]

open access: yes, 2016
A 4,000 word overview of the field of development ethics, with special reference to the interface with environmental ethics. The essay outlines characteristic concerns of development ethics, with special attention to issues around the recognition of ...
Gasper, D.R. (Des)
core   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Exploring and contextualizing public opposition to renewable electricity in the United States [PDF]

open access: yes, 2009
This article explores public opposition to renewable power technologies in the United States. It begins by discussing the genesis of environmental ethics, or how some Americans have come to place importance on the protection of the environment and ...
Allen   +44 more
core   +2 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

An Assessment of Environmental Awarness:The Role of Ethic Education

open access: yesJurnal Sains Sosial dan Humaniora, 2019
Environmental damage that occurred in Indonesia in the last three decades is due to human behavior by exploiting and depleting the universe in order to meet the interests and needs of human’s life. The objectives of this research were (1) to find out the
Indri Murniawaty
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

The Cosmology of St Maximus the Confessor as a Basis for Ecological and Humanitarian Ethics [PDF]

open access: yes, 2014
This paper explores the cosmology of St Maximus the Confessor and its relevance for contemporary ethics. It takes as it’s starting point two papers on Maximus’ cosmology and environmental ethics (Bordeianu, 2009; Munteanu, 2010) and from there argues ...
Dewhurst, Emma Brown
core  

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

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