Results 111 to 120 of about 7,641,268 (406)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Environmental exposure to arsenic and chromium in an industrial area
Environmental science and pollution research international, 2017 Arsenic and chromium are widespread environmental contaminants that affect global health due to their toxicity and carcinogenicity. To date, few studies have investigated exposure to arsenic and chromium in a population residing in a high-risk ...
L. Vimercati +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
The effect of noise on the predictive limit of QSAR models
Journal of Cheminformatics, 2021 A key challenge in the field of Quantitative Structure Activity Relationships (QSAR) is how to effectively treat experimental error in the training and evaluation of computational models.
Scott S. Kolmar, Christopher M. Grulke
doaj +1 more source
Environmental xenobiotic exposure and autoimmunity [PDF]
Current Opinion in Toxicology, 2018 Susceptibility to autoimmune diseases is dependent on multigenic inheritance, environmental factors, and stochastic events. Although there has been substantial progress in identifying predisposing genetic variants, a significant challenge facing autoimmune disease research is the identification of the specific events that trigger loss of tolerance ...
Dwight H. Kono +3 more
openaire +3 more sources
Genetic Profile, Environmental Exposure, and Their Interaction in Parkinson's Disease
Parkinson's Disease, 2016 The discovery of causative mutations for Parkinson's disease (PD) as well as their functional characterization in cellular and animal models has provided crucial insight into the pathogenesis of this disorder. Today, we know that PD pathogenesis involves
L. Polito, A. Greco, D. Seripa
semanticscholar +1 more source
Can Lessons from Public Health Disease Surveillance Be Applied to Environmental Public Health Tracking? [PDF]
, 2004 Disease surveillance has a century-long tradition in public health, and environmental data have been collected at a national level by the U.S. Environmental Protection Agency for several decades.
Balmes, John, Ritz, Beate, Tager, Ira
core +2 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Enhanced representation of soil NO emissions in the Community Multiscale Air Quality (CMAQ) model version 5.0.2 [PDF]
Geoscientific Model Development, 2016 Modeling of soil nitric oxide (NO) emissions is highly uncertain and may misrepresent its spatial and temporal distribution. This study builds upon a recently introduced parameterization to improve the timing and spatial distribution of soil NO emission ...
Q. Z. Rasool +6 more
doaj +1 more source