Results 61 to 70 of about 6,134,553 (262)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Medium-Term Lag-Response Associations Between PM10 Exposure and All-Cause Mortality in Valencia and London: A Time-Stratified Case-Crossover Study

Journal of Epidemiology and Global Health
Background Air pollution is among the top five environmental risk factors for human health worldwide. However, our understanding of the physiological responses to PM10 exposure over medium-term lag periods remains limited.
Bin Zhou, Katrin Gohlsch, Surendra Ranpal, Jiancong Wang, Christoph Knote   +4 more
doaj   +1 more source

Assessing occupational and environmental exposure [PDF]

Occupational Medicine, 2005
Exposure assessment is a poorly understood component of the science of epidemiology. The relationship between exposure to chemicals and ill-health outcomes is often calculated using crude exposure measures such as ever/never exposed or duration. When investigating subtle effects, exposures need to be characterized much more fully in terms of intensity,
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Updates to the Noah Land Surface Model in WRF‐CMAQ to Improve Simulated Meteorology, Air Quality, and Deposition

Journal of Advances in Modeling Earth Systems, 2019
Regional, state, and local environmental regulatory agencies often use Eulerian models to investigate the potential impacts on pollutant deposition and air quality from changes in land use, anthropogenic and natural emissions, and climate.
Patrick C. Campbell, Jesse O. Bash, Tanya L. Spero   +2 more
doaj   +1 more source

The formation of secondary organic aerosol from the isoprene + OH reaction in the absence of NO_x [PDF]

Atmospheric Chemistry and Physics, 2009
The reaction of isoprene (C5H8) with hydroxyl radicals has been studied in the absence of nitrogen oxides (NOx) to determine physical and chemical characteristics of the secondary organic aerosol formed.
T. E. Kleindienst, M. Lewandowski, J. H. Offenberg, M. Jaoui, E. O. Edney   +4 more
doaj   +1 more source

Environmental epigenetics in metal exposure [PDF]

Epigenetics, 2011
Although it is widely accepted that chronic exposure to arsenite, nickel, chromium and cadmium increases cancer incidence in individuals, the molecular mechanisms underlying their ability to transform cells remain largely unknown. Carcinogenic metals are typically weak mutagens, suggesting that genetic-based mechanisms may not be primarily responsible ...
Ricardo, Martinez-Zamudio, Hyo Chol, Ha
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Regional Air Quality Model Application of the Aqueous-Phase Photo Reduction of Atmospheric Oxidized Mercury by Dicarboxylic Acids

Atmosphere, 2013
In most ecosystems, atmospheric deposition is the primary input of mercury. The total wet deposition of mercury in atmospheric chemistry models is sensitive to parameterization of the aqueous-phase reduction of divalent oxidized mercury (Hg2+).
Jesse O. Bash, Annmarie G. Carlton, William T. Hutzell, O. Russell Bullock Jr.   +3 more
doaj   +1 more source