Results 61 to 70 of about 967,577 (267)

Immunoprevalence to Six Waterborne Pathogens in Beachgoers at Boquerón Beach, Puerto Rico: Application of a Microsphere-Based Salivary Antibody Multiplex Immunoassay

Frontiers in Public Health, 2017
Waterborne infectious diseases are a major public health concern worldwide. Few methods have been established that are capable of measuring human exposure to multiple waterborne pathogens simultaneously using non-invasive samples such as saliva.
Swinburne A. J. Augustine, Kaneatra J. Simmons, Tarsha N. Eason, Clarissa L. Curioso, Shannon M. Griffin, Timothy J. Wade, Alfred Dufour, G. Shay Fout, Ann C. Grimm, Kevin H. Oshima, Elizabeth A. Sams, Mary Jean See, Larry J. Wymer   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Environmental epigenetics in metal exposure [PDF]

Epigenetics, 2011
Although it is widely accepted that chronic exposure to arsenite, nickel, chromium and cadmium increases cancer incidence in individuals, the molecular mechanisms underlying their ability to transform cells remain largely unknown. Carcinogenic metals are typically weak mutagens, suggesting that genetic-based mechanisms may not be primarily responsible ...
Ricardo, Martinez-Zamudio, Hyo Chol, Ha
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Medium-Term Lag-Response Associations Between PM10 Exposure and All-Cause Mortality in Valencia and London: A Time-Stratified Case-Crossover Study

Journal of Epidemiology and Global Health
Background Air pollution is among the top five environmental risk factors for human health worldwide. However, our understanding of the physiological responses to PM10 exposure over medium-term lag periods remains limited.
Bin Zhou, Katrin Gohlsch, Surendra Ranpal, Jiancong Wang, Christoph Knote   +4 more
doaj   +1 more source

Updates to the Noah Land Surface Model in WRF‐CMAQ to Improve Simulated Meteorology, Air Quality, and Deposition

Journal of Advances in Modeling Earth Systems, 2019
Regional, state, and local environmental regulatory agencies often use Eulerian models to investigate the potential impacts on pollutant deposition and air quality from changes in land use, anthropogenic and natural emissions, and climate.
Patrick C. Campbell, Jesse O. Bash, Tanya L. Spero   +2 more
doaj   +1 more source

The formation of secondary organic aerosol from the isoprene + OH reaction in the absence of NO_x [PDF]

Atmospheric Chemistry and Physics, 2009
The reaction of isoprene (C5H8) with hydroxyl radicals has been studied in the absence of nitrogen oxides (NOx) to determine physical and chemical characteristics of the secondary organic aerosol formed.
T. E. Kleindienst, M. Lewandowski, J. H. Offenberg, M. Jaoui, E. O. Edney   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Autophagy in exposure to environmental chemicals

Toxicology Letters, 2019
Autophagy is a catabolic pathway, which breaks down old and damaged cytoplasmic material into basic biomolecules through lysosome-mediated digestion thereby recycling cellular material. In this way, autophagy prevents the accumulation of damaged cellular components inside cells and reduces metabolic stress and toxicity.
Pesonen, Maija, Vähäkangas, Kirsi
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source