Results 41 to 50 of about 1,123,096 (314)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Assessing occupational and environmental exposure [PDF]
Occupational Medicine, 2005 Exposure assessment is a poorly understood component of the science of epidemiology. The relationship between exposure to chemicals and ill-health outcomes is often calculated using crude exposure measures such as ever/never exposed or duration. When investigating subtle effects, exposures need to be characterized much more fully in terms of intensity,
openaire +2 more sources
Environmental Exposures and Hepatocellular Carcinoma [PDF]
Journal of Clinical and Translational Hepatology, 2016 Infection with hepatitis B and/or hepatitis C virus is a well-established risk factor for the development of hepatocellular carcinoma (HCC). However, it is now clear that certain occupational, environmental, and lifestyle factors also play a role in cancer development.
Santella, Regina M., Wu, Hui-Chen
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Toxics, 2023 New approach methods (NAMs) can reduce the need for chronic animal studies. Here, we apply benchmark dose (concentration) (BMD(C))–response modeling to transcriptomic changes in the liver of mice and in fathead minnow larvae after short-term exposures (7
Rubia Martin +4 more
doaj +1 more source
Fourth national report on human exposure to environmental chemicals: updated tables, January 2019, Volume one [PDF]
The Fourth Report on Human Exposure to Environmental Chemicals, Updated Tables, January 2019 (the Updated Tables, January 2019) presents nationally representative, cumulative biomonitoring data gathered from 1999\u20132000 through 2015-2016.
core +1 more source
EnvironmentOntology/environmental-exposure-ontology: December 2022 release
, 2022 What's Changed Update exposure_to_chemical.tsv by @laurenechan in https://github.com/EnvironmentOntology/environmental-exposure-ontology/pull/240 Update exposure_to_chemical_medium_route.yaml by @laurenechan in https://github.com/EnvironmentOntology ...
Chris Mungall +7 more
core +1 more source
Biomarkers of environmental manganese exposure
Critical Reviews in Toxicology, 2022 We conducted a critical review on biomarkers of environmental manganese (Mn) exposure to answer the following questions: 1) are there reliable biomarkers of internal Mn exposure (Mn in biological matrices) associated with external metrics of Mn exposure (Mn in environmental media)?
Natalia Shilnikova +9 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source