Predicting molecular initiating events using chemical target annotations and gene expression
Background The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of publicly available gene expression data associated with chemical treatments.
Joseph L. Bundy +5 more
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Adding four-dimensional data assimilation by analysis nudging to the Model for Prediction Across Scales – Atmosphere (version 4.0) [PDF]
The Model for Prediction Across Scales – Atmosphere (MPAS-A) has been modified to allow four-dimensional data assimilation (FDDA) by the nudging of temperature, humidity, and wind toward target values predefined on the MPAS-A computational mesh.
O. R. Bullock Jr. +3 more
doaj +1 more source
Environmental exposures and development [PDF]
Summarize recent studies exploring the relationship between paternal and maternal environmental exposures to chemicals before, at the time of and after conception to adverse developmental outcomes including preterm birth, death, structural and functional abnormalities and growth restriction.Recent studies have demonstrated that human pregnancy and ...
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Flood Exposure of Environmental Assets
Abstract. Environmental assets provide important benefits to society and support the equilibrium of natural processes. They can be affected by floods; however, flood risk analyses usually neglect environmental areas due to (i) a lack of agreement on what should be considered an environmental asset, (ii) a poor understanding of environmental values, and
Gabriele Bertoli +2 more
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Extending the Community Multiscale Air Quality (CMAQ) modeling system to hemispheric scales: overview of process considerations and initial applications [PDF]
The Community Multiscale Air Quality (CMAQ) modeling system is extended to simulate ozone, particulate matter, and related precursor distributions throughout the Northern Hemisphere.
R. Mathur +11 more
doaj +1 more source
Stem cells are a population of undifferentiated cells with self-renewal and differentiation capacities. Normal and cancer stem cells share similar characteristics in relation to their stemness properties.
Youssef Siblini +4 more
doaj +1 more source
Epigenetics and environmental exposures [PDF]
It is becoming increasingly apparent that genetic factors are inadequate to fully explain many processes that shape development and disease. For example, monozygotic twin pairs, despite sharing identical DNA sequences, are often discordant for many traits and diseases, indicating that the same genotype can give rise to distinct phenotypes.
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Environmental Exposures and Hearing Loss [PDF]
Pollutants that contaminate the natural or built environment adversely affect the health of living organisms. Although exposure to many of them could be avoided or minimized by careful preventive measures, it is impossible to totally avoid exposure to all pollutants.
Rita Rosati, Samson Jamesdaniel
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Long-term trends in the ambient PM2.5- and O3-related mortality burdens in the United States under emission reductions from 1990 to 2010 [PDF]
Concentrations of both fine particulate matter (PM2.5) and ozone (O3) in the United States (US) have decreased significantly since 1990, mainly because of air quality regulations.
Y. Zhang +10 more
doaj +1 more source
Osmium: An Appraisal of Environmental Exposure [PDF]
In the U.S., the chief source of new osmium is copper refining, where this metal is produced as a byproduct. Probably less than 10% of the osmium in the original copper ore is recovered, and 1000-3000 oz troy of osmium is lost each year to the environment as the toxic, volatile tetroxide from copper smelters.
I C, Smith, B L, Carson, T L, Ferguson
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