Results 71 to 80 of about 2,536,783 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Medium-Term Lag-Response Associations Between PM10 Exposure and All-Cause Mortality in Valencia and London: A Time-Stratified Case-Crossover Study

Journal of Epidemiology and Global Health
Background Air pollution is among the top five environmental risk factors for human health worldwide. However, our understanding of the physiological responses to PM10 exposure over medium-term lag periods remains limited.
Bin Zhou, Katrin Gohlsch, Surendra Ranpal, Jiancong Wang, Christoph Knote   +4 more
doaj   +1 more source

Updates to the Noah Land Surface Model in WRF‐CMAQ to Improve Simulated Meteorology, Air Quality, and Deposition

Journal of Advances in Modeling Earth Systems, 2019
Regional, state, and local environmental regulatory agencies often use Eulerian models to investigate the potential impacts on pollutant deposition and air quality from changes in land use, anthropogenic and natural emissions, and climate.
Patrick C. Campbell, Jesse O. Bash, Tanya L. Spero   +2 more
doaj   +1 more source

The formation of secondary organic aerosol from the isoprene + OH reaction in the absence of NO_x [PDF]

Atmospheric Chemistry and Physics, 2009
The reaction of isoprene (C5H8) with hydroxyl radicals has been studied in the absence of nitrogen oxides (NOx) to determine physical and chemical characteristics of the secondary organic aerosol formed.
T. E. Kleindienst, M. Lewandowski, J. H. Offenberg, M. Jaoui, E. O. Edney   +4 more
doaj   +1 more source

Environmental Exposures and Hepatocellular Carcinoma [PDF]

Journal of Clinical and Translational Hepatology, 2016
Infection with hepatitis B and/or hepatitis C virus is a well-established risk factor for the development of hepatocellular carcinoma (HCC). However, it is now clear that certain occupational, environmental, and lifestyle factors also play a role in cancer development.
Santella, Regina M., Wu, Hui-Chen
openaire   +2 more sources

Further insights on predictors of environmental tobacco smoke exposure during the pediatric age [PDF]

, 2019
Background: The smoking ban in public places has reduced Environmental Tobacco Smoke (ETS) exposure for non-smokers, but despite this, domestic environments still remain places at high risk of exposure, and, today, about 40% of children worldwide are ...
Antonucci, A., Cammalleri, V., Martellucci, S., Mattei, V., Protano, C., Santilli, F., Ungureanu, A. S., Vitali, M.   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Meta-Analysis of the Willingness to Pay for Reductions in Pesticide Risk Exposure [PDF]

The use of environmental policy instruments such as eco-labelling and pesticide taxes should preferably be based on disaggregate estimates of the individuals' willingness to pay (WTP) for pesticide risk reductions.
Florax, Raymond J.G.M., Nijkamp, Peter, Travisi, Chiara M.   +2 more
core   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source