Results 71 to 80 of about 1,123,096 (314)
Simulating lightning NO production in CMAQv5.2: evolution of scientific updates [PDF]
Geoscientific Model Development, 2019 This work describes the lightning nitric oxide (LNO) production schemes in the Community Multiscale Air Quality (CMAQ) model. We first document the existing LNO production scheme and vertical distribution algorithm.
D. Kang +6 more
doaj +1 more source
Environmental exposures in utero and microRNA
Current Opinion in Pediatrics, 2014 Understanding the effects of in-utero exposures to environmental agents is of great importance as the resulting deregulation of biological processes can affect both fetal development and health outcomes that manifest later in life. Due to their established role in developmental processes and inherent stability ex vivo, microRNAs (miRNAs) have emerged ...
Kappil, Maya, Chen, Jia
openaire +3 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Autophagy in exposure to environmental chemicals
Toxicology Letters, 2019 Autophagy is a catabolic pathway, which breaks down old and damaged cytoplasmic material into basic biomolecules through lysosome-mediated digestion thereby recycling cellular material. In this way, autophagy prevents the accumulation of damaged cellular components inside cells and reduces metabolic stress and toxicity.
Pesonen, Maija, Vähäkangas, Kirsi
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Methodology for exposure and risk assessment in complex environmental pollution situations [PDF]
, 2009 Frequently environmental pollution results from different hazardous substances released in the environment, meaning that contaminated sites may have many different chemical sources and transport pathways.
Maria de Lurdes Dinis, António Fiuza
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Retrospective Surveillance of Wastewater To Examine Seasonal Dynamics of Enterovirus Infections
mSphere, 2017 Enteroviruses are RNA viruses that are responsible for both mild gastroenteritis and mild respiratory illnesses as well as debilitating diseases such as meningitis and myocarditis.
Nichole E. Brinkman +2 more
doaj +1 more source
Environment International, 2020 Exposure to PFASs may result in adverse health effects. This study aimed to characterise the exposure to PFASs from diet, house dust, indoor air, and dermal contact and the relative contribution from different external exposure pathways to human serum ...
Somrutai Poothong +4 more
doaj +1 more source