Results 121 to 130 of about 5,663,129 (289)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effect of Ozone Exposure on Cardiovascular and Cerebrovascular Disease Mortality in the Elderly

Toxics
Background: Ozone pollution has increased alongside China’s economic development, contributing to public health issues such as cardiovascular and cerebrovascular diseases.
Tianyun Wang, Junlong Wang, Li Sun, Ye Deng, Yuting Xiang, Yuting Wang, Jiamei Chen, Wen Peng, Yuanyao Cui, Miao He   +9 more
doaj   +1 more source

Effects of some environmental factors on the fecundity of Tilapia species (Family Cichlidae) in Kigera Reservoir, New Bussa [PDF]

, 2005
The effects of some environmental factors on the fecundity of Tilapia species (Family Cichilidae) was carried out at the Kigera dam. Four Tilapia species caught were Tilapia zilli, Hemichromis fasciatus, Sarotherodon galilaeus and Oreochromis niloticus ...
Issa, E.A., Olufeagba, S.O., Raji, A.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Association between urinary mixture metal levels and olfactory function in coal miners

Frontiers in Public Health
BackgroundExposure to occupational metallic mixtures has a potential impact on olfactory function. However, research evidence is limited on the potential impact of exposure to metallic mixtures and olfactory dysfunction.
Yang Li, Yang Li, Yuxuan Jiao, Yuxuan Jiao, Rong Hu, Rong Hu, Guilin Hu, Guilin Hu, Ge Shi, Ge Shi, Kaidong Wang, Kaidong Wang, Ai Qi, Ai Qi, Yujing Li, Yujing Li, Yonghang Li, Yonghang Li, Zhuoheng Shen, Zhuoheng Shen, Jiafei Yang, Jiafei Yang, Zhiyun Ha, Zhiyun Ha, Yaowen Yang, Yaowen Yang, Jiangping Li, Jiangping Li, Jiangping Li, Min Huang, Min Huang   +30 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Relationship between skipping breakfast and metabolic syndrome among adults aged 35–74 years: a cross-sectional study in Northwest China, 2018–2020

Frontiers in Nutrition
BackgroundAlthough skipping breakfast has been associated with an increased risk of metabolic syndrome (MetS), evidence remains limited. Herein, we examined the association between breakfast skipping and MetS, as well as its individual components, among ...
Bowen Yang, Bowen Yang, Xuanxuan Zi, Xuanxuan Zi, Shenglin Peng, Shenglin Peng, Ruihan Liu, Ruihan Liu, Yangyang Cen, Yangyang Cen, Linxi Lian, Linxi Lian, Kaijun Xing, Kaijun Xing, Yi Zhao, Yi Zhao, Yannan Zhang, Yannan Zhang   +17 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Association between cooking with solid fuels and depressive symptoms among middle-aged and older adults in China: The mediating effect of the residential environment

Ecotoxicology and Environmental Safety
Background: Depression is a common issue among elderly people in both developing and developed countries. Existing research indicates that cooking with solid fuels has a negative impact on the mental health of middle-aged and elderly people (aged 45 and ...
Ximin Ma, Jiahui He, Qi Hu, Wenlong Wang, Hui Qiao   +4 more
doaj   +1 more source