Results 191 to 200 of about 20,215,705 (407)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
THE STUDENT LEARNING DIFFICULTY FACTOR XI CLASS BUILDING DRAWING LESSONS OF EXPERTISE BUILDING SMK NEGERI 3 YOGYAKARTA [PDF]
, 2011 This study aims at determine the influence of the most dominant factor OF learning difficulties of the students in Grade XI Subject Areas Building Drawing Building SMK Negeri 3 Yogyakarta, learning difficulties were factors include: (1) Internal ...
Yuyun Sigit Pramono, Yuyun Sigit Pramono
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RESEARCH OF CHILDREN CENTRE “RADOST” EXTERNAL ENVIRONMENTAL FACTORS [PDF]
, 2007 Chou, Mitch M. C. +6 more
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The Efficiency of Chlorine in Sewage Disinfection as Affected by Certain Environmental Factors [PDF]
, 1934 Willem Rudolfs, J. V. Ziemba
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Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Growth and Demographic Change: Do Environmental Factors Matter? [PDF]
We incorporate health-damaging pollution into a three period overlapping generations model in which life expectancy, fertility and economic growth are all endogenous.
Dimitrios Varvarigos +1 more
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Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
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The Influence of Environmental Factors on the Molecular Size of Dextran [PDF]
, 1953 Hyman Nadel +2 more
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source