Results 141 to 150 of about 6,324,753 (321)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Can regional and local filters explain epiphytic bryophyte distributions in the Atlantic Forest of southeastern Brazil?

Acta Botânica Brasílica, 2016
Environmental conditions in distinct tropical rainforest phytophysiognomies can act as regional filters in determining the distribution of montane bryoflora likewise, local filters inherent to phorophyte species can have modulating influences.
Wanessa Vieira Silva Menezes Batista, Nivea Dias dos Santos   +1 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Influence of Fires on Desert Plant Communities at the Chernye Zemli (SW Russia)

Fire
Understanding the rate and direction of pyrogenic succession in arid ecosystems, which depends on many factors, including the intensity of grazing and the frequency of pyrogenic expo-sure, will allow for more accurate predictions of the consequences of ...
Galya V. Klink, Sergey A. Lednev, Ivan N. Semenkov, Maria V. Konyushkova, Andrey M. Karpachevskiy, Mergen M. Chemidov, Svetlana S. Ulanova, Natal’ya L. Fedorova, Anna V. Sharapova, Sergey A. Bogun, Tatyana V. Koroleva   +10 more
doaj   +1 more source

Polluting emissions and GDP : decoupling evidence from brazilian states [PDF]

, 2019
We provide a comprehensive analysis of the relationship between greenhouse gas (GHG) emissions and GDP in Brazil using both aggregate and state-level data.
Jalles, João Tovar
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

STUDYING REGULARITIES OF AIR MOVEMENT THROUGH A FILTERING HALF-MASK [PDF]

, 2018
Objective is to study the available approaches to calculate pressure difference of filtering respirators, to determine theoretical dependences of its change in terms of different filtering rate according to the breathing process with the ...
CHEBERIACHKO, Sergiy, TYKHONENKO, Valeriia, YAVORSKYI, Andrii, YAVORS’KA, Olena, Чеберячко, С. І., Чеберячко, Сергей Иванович, Чеберячко, Сергій Іванович, Яворская, Е. А., Яворская, Елена Александровна, Яворский, А. В., Яворский, Андрей Васильевич, Яворська, О. О., Яворська, Олена Олександрівна, Яворський, А. В., Яворський, Андрій Васильович   +14 more
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

MULTI AGENT-BASED ENVIRONMENTAL LANDSCAPE (MABEL) - AN ARTIFICIAL INTELLIGENCE SIMULATION MODEL: SOME EARLY ASSESSMENTS [PDF]

The Multi Agent-Based Environmental Landscape model (MABEL) introduces a Distributed Artificial Intelligence (DAI) systemic methodology, to simulate land use and transformation changes over time and space.
Alexandridis, Konstantinos T., Pijanowski, Bryan C.   +1 more
core   +1 more source