Results 121 to 130 of about 175,424 (290)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Influence of Fires on Desert Plant Communities at the Chernye Zemli (SW Russia)

Fire
Understanding the rate and direction of pyrogenic succession in arid ecosystems, which depends on many factors, including the intensity of grazing and the frequency of pyrogenic expo-sure, will allow for more accurate predictions of the consequences of ...
Galya V. Klink, Sergey A. Lednev, Ivan N. Semenkov, Maria V. Konyushkova, Andrey M. Karpachevskiy, Mergen M. Chemidov, Svetlana S. Ulanova, Natal’ya L. Fedorova, Anna V. Sharapova, Sergey A. Bogun, Tatyana V. Koroleva   +10 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Biotic interactions and environmental filtering both determine earthworm alpha and beta diversity in tropical rainforests

Understanding the relative importance of biotic interactions, multiple environmental drivers, and neutral processes in shaping community diversity and composition is a central question for both theoretical and applied ecology.
Maggia, Marie-Eugénie, Hedde, Mickaël, Marcon, Eric, Goulpeau, Arnaud, Ganault, Pierre, Lapied, Emmanuel, Decaëns, Thibaud   +6 more
core   +2 more sources

Environmental filtering, not dispersal history, explains global patterns of phylogenetic turnover in seed plants at deep evolutionary timescales

Acknowledgements L.C. and M.W. acknowledge the German Research Foundation (DFG) funding via iDiv (DFG FZT 118, 202548816). H.K. acknowledges funding from DFG Research Training Group 1644 ‘Scaling problems in statistics’ (grant no. 152112243) and Research
Pergl, Jan, van Kleunen, M, Wieringa, JJ, Dawson, Wayne, Weigelt, Patrick, Craven, D, Wagner, V, Winter, Marten, Craven, Dylan, Pyšek, P, Winter, M, Cai, L, Cai, Lirong, Dawson, W, Essl, F, Cabezas, FJ, Essl, Franz, Taylor, A, Pyšek, Petr, Denelle, Pierre, Kreft, H, Weigelt, P, Kreft, Holger, Denelle, P, Pergl, J, Taylor, Amanda, Wieringa, Jan J., van Kleunen, Mark, Wagner, Viktoria, Cabezas Fuentes, Francisco José, Pelser, PB, Pelser, Pieter B.   +31 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

The interplay between host-specificity and habitat-filtering influences sea cucumber microbiota across an environmental gradient of pollution [PDF]

Environmental gradients can influence morpho-physiological and life-history differences in natural populations. It is unclear, however, to what extent such gradients can also modulate phenotypic differences in other organismal characteristics such as the
Zhenzhen Li, Chung, Sheena Suet-Wah, Chung, Sheena Suet Wah, Bovern Suchart Arromrak, Cheung, Khan, Sheena Suet-Wah Chung, Gaitán-Espitia, Juan Diego, Khan Cheung, Arromrak, Bovern Suchart, Li, Zhenzhen, Cham Man Tse, Tse, Cham Man, Juan Diego Gaitán-Espitia   +12 more
core   +1 more source