Results 101 to 110 of about 6,324,753 (321)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Anthropogenic Pressure and Climate Change Could Severely Hamper the Avian Metacommunity of the Sicilian Wetlands

Diversity, 2022
Our study shows that the current levels of anthropogenic exploitation of the Sicilian wetlands (Italy), combined with the likely exacerbation of climate-driven variables, are unsustainable and could soon exclude many bird species from this metacommunity.
Alessandro Ferrarini, Claudio Celada, Marco Gustin   +2 more
doaj   +1 more source

Attenuation of Environmental Noise through Digital Filtering

, 2021
This chapter proposes the implementation of an environmental noise cancelation system using the least mean squares algorithm with noise amplitude modulation (NAMLMS). The system was implemented in a dsPIC3020F10 digital processor. The results obtained demonstrate that low- and high-frequency signals are attenuated allowing the passage of an audible ...
Juan, Ríos,, Celedonio, Aguilar,
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Elevational Patterns of Generic Diversity in the Tenebrionid Beetles (Coleoptera Tenebrionidae) of Latium (Central Italy)

Diversity, 2020
The concept of generic diversity expresses the ‘diversification’ of species into genera in a community. Since niche overlap is assumed to be higher in congeneric species, competition should increase generic diversity.
Simone Fattorini, Cristina Mantoni, Letizia Di Biase, Giovanni Strona, Loretta Pace, Maurizio Biondi   +5 more
doaj   +1 more source

Health without filters: the health and environmental impacts of cigarette filters.

Ciencia & saude coletiva, 2021
Tobacco-related diseases kill eight million people worldwide ever year and are responsible for thousands of cases of cancer, cardiovascular disease and other illnesses in Brazil. Cigarette filters are believed by many to reduce the health risks of smoking. This article outlines the history of the technology of filters and discusses the impacts of these
André Luiz Oliveira da, Silva, Stefania Schimaneski, Piras, Stella Aguinaga, Bialous, Josino Costa, Moreira   +3 more
openaire   +1 more source

Environmental filtering governs the spatial distribution of alien fishes in a large, human‐impacted Mediterranean river

Diversity and Distributions: A journal of biological invasions and biodiversity, 2019
To analyse the occurrence and abundance of native versus alien fish species in relation to climate, land use, hydrologic alteration and habitat fragmentation in a heavily invaded and human‐impacted riverine ecosystem.
J. Radinger, Juan Diego Alcaraz‐Hernández, E. García‐Berthou   +2 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Real-Time odor classification through sequential bayesian filtering [PDF]

, 2015
The classification of volatiles substances with an e-nose is still a challenging problem, particularly when working under real-time, out-of-the-lab environmental conditions where the chaotic and highly dynamic characteristics of the gas transportation ...
Gonzalez-Jimenez, Antonio Javier, Monroy, Javier G.   +1 more
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