Results 81 to 90 of about 175,424 (290)

Health without filters: the health and environmental impacts of cigarette filters.

Ciencia & saude coletiva, 2021
Tobacco-related diseases kill eight million people worldwide ever year and are responsible for thousands of cases of cancer, cardiovascular disease and other illnesses in Brazil. Cigarette filters are believed by many to reduce the health risks of smoking. This article outlines the history of the technology of filters and discusses the impacts of these
André Luiz Oliveira da, Silva, Stefania Schimaneski, Piras, Stella Aguinaga, Bialous, Josino Costa, Moreira   +3 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Dispersal versus environmental filtering in a dynamic system : Drivers of vegetation patterns and diversity along stream riparian gradients

, 2015
Both environmental filtering and dispersal filtering are known to influence plant species distribution patterns and biodiversity. Particularly in dynamic habitats, however, it remains unclear whether environmental filtering (stimulated by stressful ...
Fraaije, R.G.A., Verhoeven, Jos T.A., Braak, C.J.F., ter, Verduyn, Betty, Soons, M.B., Verduyn, B., Verhoeven, J.T.A.   +6 more
core   +2 more sources

Elevational Patterns of Generic Diversity in the Tenebrionid Beetles (Coleoptera Tenebrionidae) of Latium (Central Italy)

Diversity, 2020
The concept of generic diversity expresses the ‘diversification’ of species into genera in a community. Since niche overlap is assumed to be higher in congeneric species, competition should increase generic diversity.
Simone Fattorini, Cristina Mantoni, Letizia Di Biase, Giovanni Strona, Loretta Pace, Maurizio Biondi   +5 more
doaj   +1 more source

Environmental filtering decreases with fish development for the assembly of gut microbiota

, 2016
Gut microbiota typically occupy habitats with definable limits/borders that are comparable to oceanic islands. The gut therefore can be regarded as an 'island' for the assembly of microbial communities within the 'sea' of surrounding environments.
Xinghao Li, Kempher, Megan L., Ni, Jiajia, Wu, Liyou, Wang, Chun, Jizhong Zhou, Li, Jinjin, Wu, Shu, He, Zhili, Jinjin Li, Lanjie Liao, Zhou, Jizhong, Jianjun Wang, Wang, Jianjun, Yaping Wang, Chun Wang, Van Nostrand, Joy D, Yuhe Yu, Megan L. Kempher, Van Nostrand, Joy D., Yan, Qingyun, Zhili He, Li, Xinghao, Liao, Lanjie, Yu, Yuhe, Joy D. Van Nostrand, Jiajia Ni, Liyou Wu, Shu Wu, Qingyun Yan, Wang, Yaping, Kempher, Megan L   +31 more
core   +1 more source

An experimental test of environmental filtering in zooplankton pond communities

, 2023
Examine the influence of environmental filtering on the zooplankton community structure in a group of ponds within an agricultural ...
Victor Parry (12703649)
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Insights into the effects of environmental factors on phytoplankton and microzooplankton at a basin scale: diversity, assembly mechanisms, and co-occurrence networks

Frontiers in Marine Science
Mastering the characteristics of planktonic microbial communities under the influence of basin-scale environmental factors can provide scientific basis to develop more targeted protection and restoration measures. Here, an environmental DNA metabarcoding
Yanjun Shen, Yanjun Shen, Xinxin Zhou, Xinxin Zhou, Jiaming Zhang, Jiaming Zhang, Qinghua Li, Qinghua Li, Yufeng Zhang, Yufeng Zhang, Qing Zuo, Qing Zuo   +11 more
doaj   +1 more source