Results 61 to 70 of about 175,424 (290)
Microorganisms, 2022 Ciliates are a group of phagotrophic protists found in a wide variety of ecosystems. This study builds on recent studies of ciliates in the Krka river and investigates changes in the phylogenetic and functional diversity of ciliates in biofilm to predict
Vesna Gulin Beljak +9 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Developmental toxicity of UV filters and environmental exposure: a review [PDF]
International Journal of Andrology, 2008 SummarySeveral ultraviolet (UV) filters exhibit estrogenic, some also anti‐androgenic activity. They are present in waste water treatment plants, surface waters and biosphere including human milk, suggesting potential exposure during development. Developmental toxicity was studied in rats for the UV filters 4‐methylbenzylidene camphor (4‐MBC, 0.7, 7 ...
Schlumpf M +12 more
openaire +3 more sources
Insects, 2022 The large-scale spatial variation in and causes of biotic turnover of soil fauna remain poorly understood. Analyses were conducted based on published data from 14 independent sampling sites across five forest ecosystems in East Asia. Jaccard and Sørensen’
Peikun Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Intercontinental trends in functional and phylogenetic structure of stream fish assemblages
Ecology and Evolution, 2019 Understanding of community assembly has been improved by phylogenetic and trait‐based approaches, yet there is little consensus regarding the relative importance of alternative mechanisms and few studies have been done at large geographic and ...
Luke M. Bower, Kirk O. Winemiller
doaj +1 more source
Community assembly, functional traits, and phylogeny in Himalayan river birds
Ecology and Evolution, 2022 Heterogeneity in riverine habitats acts as a template for species evolution that influences river communities at different spatio‐temporal scales. Although birds are conspicuous elements of these communities, the roles of phylogeny, functional traits ...
Ankita Sinha +3 more
doaj +1 more source
Data from: Environmental filtering improves ecological niche models across multiple scales
, 2019 1. A clear challenge for ecological niche modeling is determining how to best mitigate the effects of sampling bias from commonly collected biodiversity data.
Castellanos, Adrian A. +7 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source