Results 61 to 70 of about 166,986 (256)

Health without filters: the health and environmental impacts of cigarette filters.

Ciencia & saude coletiva, 2021
Tobacco-related diseases kill eight million people worldwide ever year and are responsible for thousands of cases of cancer, cardiovascular disease and other illnesses in Brazil. Cigarette filters are believed by many to reduce the health risks of smoking. This article outlines the history of the technology of filters and discusses the impacts of these
André Luiz Oliveira da, Silva, Stefania Schimaneski, Piras, Stella Aguinaga, Bialous, Josino Costa, Moreira   +3 more
openaire   +1 more source

Feature-preserving interpolation and filtering of environmental time series [PDF]

Environmental Modelling & Software, 2015
6 pages, 4 ...
Grégoire Mariéthoz, Niklas Linde, Damien Jougnot, Hassan Rezaee   +3 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Insights into the effects of environmental factors on phytoplankton and microzooplankton at a basin scale: diversity, assembly mechanisms, and co-occurrence networks

Frontiers in Marine Science
Mastering the characteristics of planktonic microbial communities under the influence of basin-scale environmental factors can provide scientific basis to develop more targeted protection and restoration measures. Here, an environmental DNA metabarcoding
Yanjun Shen, Yanjun Shen, Xinxin Zhou, Xinxin Zhou, Jiaming Zhang, Jiaming Zhang, Qinghua Li, Qinghua Li, Yufeng Zhang, Yufeng Zhang, Qing Zuo, Qing Zuo   +11 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Elevational Patterns of Generic Diversity in the Tenebrionid Beetles (Coleoptera Tenebrionidae) of Latium (Central Italy)

Diversity, 2020
The concept of generic diversity expresses the ‘diversification’ of species into genera in a community. Since niche overlap is assumed to be higher in congeneric species, competition should increase generic diversity.
Simone Fattorini, Cristina Mantoni, Letizia Di Biase, Giovanni Strona, Loretta Pace, Maurizio Biondi   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Population Structure and Climate Effects on Geckobia Infestation in Ptyodactylus Geckos from Israel and West Bank, with Descriptions of G. parva sp. nov. and G. inermis sp. nov.

Animals
Scale mites of the genus Geckobia (Pterygosomatidae) are highly specialized permanent parasites of geckos, but their diversity and ecology in arid environments remain poorly understood.
Monika Fajfer-Jakubek, Bożena Sikora
doaj   +1 more source