Results 71 to 80 of about 166,986 (256)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Environmental Drivers Override Host Phylogeny in a Locoweed–Endophyte Symbiosis

Journal of Fungi
Plant endophytes, often termed the “second genome”, critically shape host adaptability. However, the complexity of their interactions, regulated by microbial traits, host species, and environment, has limited both our understanding of symbiosis and the ...
Yue-Yang Zhang, Tong-Tong Wang, Yan-Zhong Li   +2 more
doaj   +1 more source

Environmental filtering determines metacommunity structure in wetland microcrustaceans

Oecologia, 2016
Metacommunity approaches are becoming popular when analyzing factors driving species distribution at the regional scale. However, until the popularization of the variation partitioning technique it was difficult to assess the main drivers of the observed patterns (spatial or environmental).
Gascón Garcia, Stéphanie, Arranz, Ignasi, Cañedo Argüelles, Miguel, Nebra, Alfonso, Ruhí i Vidal, Albert, Rieradevall i Sant, Maria, Caiola, Nuno, Sala Genoher, Jordi, Ibàñez, Carles, Quintana Pou, Xavier, Boix Masafret, Dani   +10 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Thermal Niche Differentiation Shapes the Hibernating Bat Assemblages in Bulgarian Caves Across an Elevational Gradient

Biology
Elevation is a strong proxy for the thermal environment because it causes a predictable drop in temperature and food availability. This restricts cave-dwelling bats to species with specific metabolic traits, such as torpor or migration to avoid cold ...
Heliana Dundarova, Ilya Acosta-Pankov, Elena Nedyalkova, Andrea Lubenova, Maksim Kolev, Krasimir Kirov, Krasimir Lakovski, Olya Genova, Valeri Parvanov, Plamenka Iskrenova, Vladimir Trifonov, Tsenka Chassovnikarova   +11 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Multi-Dimensional Characterization of Seasonal Phytoplankton Community Dynamics in Urban Water Bodies of Beijing

Diversity
Phytoplankton play a central role in aquatic ecosystems as primary producers and serve as key bioindicators of water quality. This study systematically examined the seasonal dynamics (spring, summer, autumn) of phytoplankton communities in Beijing’s ...
Dongxia Wang, Bo Liu, Yaqi Wang, Jie Yang, Tingting Du, Kena Shi, Shuai Yang, Shaokai Xiong, Lei Guo, Ranran Ding, Zhen Cheng, Yu Peng, Yuxin Hu   +12 more
doaj   +1 more source

Large-scale patterns in morphological diversity and species assemblages in Neotropical Triatominae (Heteroptera: Reduviidae)

Memorias do Instituto Oswaldo Cruz, 2013
We analysed the spatial variation in morphological diversity (MDiv) and species richness (SR) for 91 species of Neotropical Triatominae to determine the ecological relationships between SR and MDiv and to explore the roles that climate, productivity ...
Paula Nilda Fergnani, Adriana Ruggiero, Soledad Ceccarelli, Frederic Menu, Jorge Rabinovich   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source