Results 71 to 80 of about 5,130,708 (243)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Environmental Drivers Override Host Phylogeny in a Locoweed–Endophyte Symbiosis

Journal of Fungi
Plant endophytes, often termed the “second genome”, critically shape host adaptability. However, the complexity of their interactions, regulated by microbial traits, host species, and environment, has limited both our understanding of symbiosis and the ...
Yue-Yang Zhang, Tong-Tong Wang, Yan-Zhong Li   +2 more
doaj   +1 more source

Investigating the memory requirements for publish/subscribe filtering algorithms [PDF]

, 2005
Various filtering algorithms for publish/subscribe systems have been proposed. One distinguishing characteristic is their internal representation of Boolean subscriptions: They either require conversions to disjunctive normal forms (canonical approaches)
Bittner, Sven, Hinze, Annika
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Thermal Niche Differentiation Shapes the Hibernating Bat Assemblages in Bulgarian Caves Across an Elevational Gradient

Biology
Elevation is a strong proxy for the thermal environment because it causes a predictable drop in temperature and food availability. This restricts cave-dwelling bats to species with specific metabolic traits, such as torpor or migration to avoid cold ...
Heliana Dundarova, Ilya Acosta-Pankov, Elena Nedyalkova, Andrea Lubenova, Maksim Kolev, Krasimir Kirov, Krasimir Lakovski, Olya Genova, Valeri Parvanov, Plamenka Iskrenova, Vladimir Trifonov, Tsenka Chassovnikarova   +11 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Multi-Dimensional Characterization of Seasonal Phytoplankton Community Dynamics in Urban Water Bodies of Beijing

Diversity
Phytoplankton play a central role in aquatic ecosystems as primary producers and serve as key bioindicators of water quality. This study systematically examined the seasonal dynamics (spring, summer, autumn) of phytoplankton communities in Beijing’s ...
Dongxia Wang, Bo Liu, Yaqi Wang, Jie Yang, Tingting Du, Kena Shi, Shuai Yang, Shaokai Xiong, Lei Guo, Ranran Ding, Zhen Cheng, Yu Peng, Yuxin Hu   +12 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Multiscale patterns of sponge diversity on Western Atlantic coral reefs: insights from the Southern Gulf of Mexico and the Mexican Caribbean

Frontiers in Marine Science
IntroductionSponges are increasingly dominant components of coral reefs in the Tropical Western Atlantic, yet patterns of their diversity across spatial scales remain poorly quantified.MethodsWe applied a hierarchical sampling design across 13 reefs and ...
Diana Ugalde, Nuno Simões, Nuno Simões, Nuno Simões, María Cristina Díaz, María Cristina Díaz, Edlin Guerra-Castro, Edlin Guerra-Castro   +7 more
doaj   +1 more source