Results 71 to 80 of about 71,585 (251)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Projected patterns of land uses in Africa under a warming climate

Scientific Reports
Land-use change is a direct driver of biodiversity loss, projection and future land use change often consider a topical issue in response to climate change. Yet few studies have projected land-use changes over Africa, owing to large uncertainties.
Ibrahim Yahaya, Runhong Xu, Jian Zhou, Shan Jiang, Buda Su, Jinlong Huang, Jing Cheng, Zhibo Dong, Tong Jiang   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Collaborative energy visioning under conditions of illiberal democracy: results and recommendations from Ecuador

Energy, Sustainability and Society, 2018
Background Sociotechnical transitions require pressure to be exerted from inside or outside of the prevailing ‘regime’, without which various path dependencies combine to maintain the status quo.
Eduardo Noboa, Paul Upham, Harald Heinrichs   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

GOOD ENVIRONMENTAL GOVERNANCE (STUDI KASUS PENGELOLAAN TAMAN MACAN DI KOTA MAKASSAR

Otoritas: Jurnal Ilmu Pemerintahan, 2015
This study aims to determine the government's efforts and collaboration between government, private sektor and communities in the management of one of the parks in the city of Makassar are tiger parks to realize that good environmental governance.
Nur Faisah, Andi Luhur Prianto
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The emancipatory inclusion of nonhuman animals in the Dutch sustainable food system transition: An embodied critical discourse analysis

Earth System Governance
There is increasing agreement among scientists and policy makers that we need transformative change, change at the deepest levels of society, to become sustainable.
Anne van Veen, Ingrid Visseren-Hamakers
doaj   +1 more source

Improving Unsustainable Environmental Governance in South Africa: the Case for Holistic Governance [PDF]

Potchefstroom Electronic Law Journal, 2006
Environmental law in South Africa has developed in a rapid fashion since the inception of the new constitutional dispensation in 1994. This development is evident from, inter alia, the constitutionalisation of the environmental right in section 24 of the
LJ Kotze
doaj  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source