Results 71 to 80 of about 6,431,843 (292)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Environmental Systems and Local Actors: Decentralizing Environmental Policy in Uganda [PDF]

, 2010
In Uganda, environmental and natural resource management is decentralized and has been the responsibility of local districts since 1996. This environmental management arrangement was part of a broader decentralization process and was intended to increase
Oosterveer, P.J.M., Vliet, B.J.M., van, Bas Van Vliet, Peter Oosterveer   +3 more
core   +1 more source

EUROPEAN VALUES IN ENVIRONMENTAL GOVERNANCE OF THE EASTERN PARTNERSHIP COUNTRIES

Міжнародні відносини: теоретико-практичні аспекти, 2018
Main objective of the study is the analysis of the environmental governance in the Eastern Partnership countries. Methodology of the study includes an analysis of the European Union and the countries of the Eastern Partnership documents devoted to the ...
Tetiana Perha
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Disentangling Scale Approaches in Governance Research: Comparing Monocentric, Multilevel, and Adaptive Governance [PDF]

, 2010
The question of how to govern the multiscale problems in today's network society is an important topic in the fields of public administration, political sciences, and environmental sciences.
Lieshout, M. van, Catrien J.A.M. Termeer, Maartje van. Lieshout, Termeer, C.J.A.M., Dewulf, A.R.P.J., Art Dewulf, Maartje van Lieshout, Dewulf, A., Lieshout, M., van   +8 more
core   +1 more source

Improving Unsustainable Environmental Governance in South Africa: the Case for Holistic Governance [PDF]

Potchefstroom Electronic Law Journal, 2006
Environmental law in South Africa has developed in a rapid fashion since the inception of the new constitutional dispensation in 1994. This development is evident from, inter alia, the constitutionalisation of the environmental right in section 24 of the
LJ Kotze
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hybrid accountability in cooperative initiatives for global climate governance [PDF]

, 2019
An examination of whether accountability mechanisms in global environmental governance that focus on monitoring and enforcement necessarily lead to better governance and better environmental ...
Widerberg, O.E., Pattberg, P.H., Park, Susan, Kramarz, Teresa, Brouwer, Lieke   +4 more
core   +1 more source

Mapping municipal food supply: A longitudinal‐spatial case study in Southern Germany

Urban Agriculture & Regional Food Systems
German food supply structures show heavy market concentration, which is often framed as a result of economies of scale and scope, individual purchasing behavior, and restrictive EU regulations.
Elena Mager, Martin Ritter, David Sipple, Heiner Schanz   +3 more
doaj   +1 more source