Results 31 to 40 of about 2,135,040 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

National Center for Environmental Health [PDF]

open access: yes
The National Center for Environmental Health (NCEH) protects America\u2019s health from environmental hazards. NCEH monitors health outcomes and environmental exposures to guide actions that protect and promote health.For more information visit https ...

core   +2 more sources

The impact of improper waste disposal on human health and the environment: a case of Umgungundlovu District in KwaZulu Natal Province, South Africa

open access: yesFrontiers in Sustainability
IntroductionWaste generation has increased drastically around the world in recent decades, with less than 20% of waste recycled each year, and one-third of all food produced wasted.
Tlou Raphela   +2 more
doaj   +1 more source

Survey of float tank operating practices

open access: yesJournal of Water and Health, 2023
Float tanks are recreational water baths with high concentrations of MgSO4 used for sensory deprivation. Documentation on standard operating practices within float tank facilities is lacking, which is useful for understanding the need for regulation. The
Laura Michele Suppes   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The DaNa projects: public communication of (nano)material safety data—from conspiracy theories to study quality

open access: yesFrontiers in Toxicology
In this perspective, the authors give their view on the developments and experiences on communicating on (nano)materials safety. We would like to share our experiences with the scientific community in order to make them useful for future communication ...
Dana Kühnel   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identify the Challenges of Sustainable Agricultural Development in the South of Kerman Province [PDF]

open access: yesجغرافیا و پایداری محیط, 2019
The use of unconditional production inputs to increase performance over the last decade which leads to the degradation of the environment and human health, has underscored the importance of sustainable agriculture and continued production along with the ...
Omid Sharifi   +2 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A National strategy to revitalize environmental public health services [PDF]

open access: yes
"The process of developing the Centers for Disease Control and Prevention's (CDC's) National Strategy to Revitalize Environmental Public Health Services required input from stakeholders representing all areas of environmental public health.

core   +4 more sources

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