Results 51 to 60 of about 1,695,337 (264)

L'approche écosystémique de la santé des populations : le cas de l’exposition au mercure des communautés riveraines de l’Amazonie et du nord du Québec

Développement Durable et Territoires, 2013
The environmental mercury issue is complex and the subclinical impacts of a long-term exposure to low concentrations have often failed to be taken into account.
Sebastian Weissenberger, Delaine Sampaio da Silva, Roger Schetagne   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Human Health Risk Assessment of PM2.5, NO2, and SO2 and its Impact on Mortality in Nkangala and Gert Sibande, South Africa

Annals of Global Health
Introduction: Located in Mpumalanga’s Highveld Priority Area (HPA), Nkangala and Gert Sibande are well‑known for sustained exposure to high levels of air pollution, which is linked to adverse health effects.
Danielle A Millar, Marcus A Howard, Natasha Naidoo, Thandi Kapwata, Riëtha Oosthuizen, Caradee Wright   +5 more
doaj   +1 more source

Traitement des déchets et santé environnementale : la science, un facteur d’acceptabilité locale ? L’exemple de l’incinérateur à Fos-sur-Mer

Développement Durable et Territoires, 2013
Environmental health considerations appear to have created a focal point for the local mobilization of indigenous and grassroots resistance to waste management.
Isabelle Hajek
doaj   +1 more source

The association of exposure to PM 10 with the quality of life in adult asthma patients

International Journal of Occupational Medicine and Environmental Health, 2020
Objectives Air pollution has become a critical environmental issue, which severely threatens the well-being of asthma patients. The quality of life of these patients, when exposed to air pollutants such as particulate matter 10 (PM 10 ), has been poorly ...
Monika Ścibor, Marta Malinowska-Cieślik   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Impact of Green Building Implementation on Health and Well-being of Building Users in Indonesia

Jurnal Presipitasi
This research conducts a systematic literature review, adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, to examine the impact of green building implementation on health and well-being of users in Indonesia.
Lendra Lendra, Jesica Jesica, Ruliana Febrianty   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Neurological and mental health in the era of climate change: mechanisms, clinical impacts, and adaptation

Frontiers in Public Health
Climate change has become a global health emergency in recent decades, with far-reaching effects on neurological and psychiatric health; however, their relationship remains poorly understood.
Pablo S. Martínez Lozada, Jose E. Leon-Rojas   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source