Results 51 to 60 of about 1,784,614 (264)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Bookshelf on Environmental Health [PDF]

open access: yesAmerican Journal of Public Health and the Nations Health, 1962
FROMI the earliest times environmental sanitation has been a basic area of community action in the interest of health. However, in the past decade it has taken on the New Look which is l)eing referred to as environmental health. It represents the collective knowledge of the human race on environmental influences as theyaffect health and well-being.
openaire   +2 more sources

Environmental and Occupational Exposures in Immigrant Health

open access: yesEnvironmental Health Insights, 2008
Immigrants comprise vulnerable populations that are frequently exposed to a multitude of environmental and occupational hazards. The historical context behind state and federal legislation has helped to foster an environment that is particularly hostile ...
Pracha P. Eamranond, Howard Hu
doaj  

Reframing the environment domain of the nursing metaparadigm: Exploring space, place, and technology

open access: yesBelitung Nursing Journal
Metaparadigms differentiate disciplines in terms of how each discipline develops its knowledge and its scholarship. In nursing, four domains comprise the nursing metaparadigm, namely: environment, person, health, and nursing.
Epifania Marlene Purisima   +4 more
doaj   +1 more source

Socio-economic, infrastructural and health-related risk factors associated with adverse heat-health effects reportedly experienced during hot weather in South Africa

open access: yesThe Pan African Medical Journal, 2019
INTRODUCTION: Poor urban communities are likely to bear the brunt of climate change impacts on health and well-being. The City of Johannesburg, South Africa, is predicted to experience an average increase in ambient temperature of 4,C by 2100.
Caradee Yael Wright   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Insights into the Evolution of Environmental Health

open access: yesEnvironmental Health Insights, 2009
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Timothy Kelley
doaj  

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