Results 71 to 80 of about 1,784,614 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
[Environmental health in Peru].
Revista peruana de medicina experimental y salud publica, 2014 -
Gustavo F. Gonzales, Kyle Steenland
openaire +2 more sources
A case study of long-term disease burden in a rural community near an open burn facility
Experimental Biology and MedicineOpen burning and open detonation (OB/OD) of explosive and hazardous wastes creates various toxic waste products, including particulate matter, that is released into the atmosphere and capable of generating significant health impacts upon exposure.
Arundhati Bakshi +6 more
doaj +1 more source
Environmental disease monitoring by regional Environmental Health Centers in Korea: a narrative review [PDF]
The Ewha Medical JournalThis study explores the development, roles, and key initiatives of the Regional Environmental Health Centers in Korea, detailing their evolution through four distinct phases and their impact on environmental health policy and local governance.
Myung-Sook Park +20 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
International Journal of Occupational Medicine and Environmental HealthObjectives Exposure to nighttime light pollution has a multidimensional environmental impact and is associated with harmful health effects. This study aimed to characterize individual interventions to reduce nighttime light exposure among adults in ...
Radosław Sierpiński +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Seizures, climate and pollution: is there evidence of an association?
Frontiers in Public HealthBackgroundEpilepsy, a chronic neurological disorder affecting more than 65 million people worldwide, is characterized by recurrent seizures caused by abnormal neuronal discharges.
Cecilia Llobet +6 more
doaj +1 more source
Environmental health community service: Confronting the human resource challenges
SA Journal of Human Resource Management, 2019 Orientation: The environmental health graduates are required to complete community service before they could be registered as independent practitioners by the Health Professions Council of South Africa. Community service programme serves as the mechanism
Patience Mbola +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source