Results 51 to 60 of about 1,488,359 (310)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Building a children's health and environment research agenda in Alberta, Canada: A multi-stakeholder engagement process

Gateways, 2019
As new environmental exposures are continuously identified, environmental influences on health are of growing concern. Knowledge regarding the impacts of environmental exposures is constantly evolving and is often incomplete. In this paper, we describe a
Osnat Wine, Irena Buka, Alan Day, Susan Terris, Mary-Ann Clarkes, Lesley Brennan, Alvaro Osornio Vargas, Katharina Kovacs Burns   +7 more
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Metal Pollution in Nigeria: A Biomonitoring Update

Journal of Health and Pollution, 2014
Background. Heavy metal contamination has become a challenge in Nigerian cities. Objective. This review updates our current understanding of the environmental health effects of metal pollution in Nigeria. Methods.
Orish Ebere Orisakwe, PhD, Jason L. Blum, PhD, Sabina Sujak, MSc, Judith T. Zelikoff, PhD   +3 more
doaj   +1 more source

Environmentally vulnerable or sensitive groups exhibiting varying concerns toward air pollution can drive government response to improve air quality

iScience, 2022
Summary: Air pollution seriously threatens human health, and its consequences are particularly prevalent among environmentally vulnerable or sensitive groups.
Z.H. Wang, W.H. Zhao, B. Wang, J. Liu, S.L. Xu, B. Zhang, Y.F. Sun, H. Shi, D.B. Guan   +8 more
doaj  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Eighth Annual Conference of inVIVO Planetary Health on Transforming Life: Unify Personal, Public, and Planetary Health

Challenges, 2018
inVIVO Planetary Health is a progressive, humanist scientific movement promoting both evidence and advocacy around concepts of planetary health which denote the interdependence between human health and place at all scales.
Susan L. Prescott, Anita L. Kozyrskyj, Alan C. Logan, Dianne E. Campbell   +3 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Environmental and Occupational Exposures in Immigrant Health

Environmental Health Insights, 2008
Immigrants comprise vulnerable populations that are frequently exposed to a multitude of environmental and occupational hazards. The historical context behind state and federal legislation has helped to foster an environment that is particularly hostile ...
Pracha P. Eamranond, Howard Hu
doaj