Results 101 to 110 of about 362,096 (260)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Habitat heterogeneity and use of physical and acoustic space in anuran communities in Southeastern Brazil

Phyllomedusa: Journal of Herpetology, 2008
We intended to verify if structural and physiognomical characteristics of water bodies influence on the degree of overlap among calling sites of 23 anurans species, if anuran species use different calling sites in different water bodies, and if there is ...
Tiago da Silveira Vasconcelos, Denise de Cerqueira Rossa-Feres   +1 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Environmental instability in heterogeneous domains

, 2016
Species interaction models have been widely studied to investigate the phenomena of population fluctuations and extinction. To a great degree, these models have assumed that the environment is spatially homogeneous, although discrete 'patch models' suggested that movement between patches has important global implications.
Maini, P, Benson, D, Sherratt, J
openaire   +1 more source

Heterogeneous relations among environmental regulation, technological innovation, and environmental pollution

Heliyon
In this study, interprovincial panel data of China from 2011 to 2020 are selected and empirically examined to determine the effects of three types of environmental regulation tools: command-and-control, market-incentive, and public-participation types. Then, hierarchical regression analysis and instrumental variables are used to analyze and verify the ...
Zhilong You, Guisheng Hou, Min Wang
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

High intensity human activity limits ultra-high altitude soil microbial community dispersal and keystone taxa distribution in southeastern Tibetan Plateau

Frontiers in Microbiology
Increasing human activities have caused ecological damage to the environment, especially in the ecologically sensitive alpine regions such as the southeastern Tibetan Plateau.
Wenzu Liu, Wenzu Liu, Hongfang Ma, Mengyao Dong, Mengyao Dong, Yaning Song, Ruihong Wang, Zhuonan Hou, Zhuonan Hou, Daqing Luo, Heping Ma, Yuquan Wei, Yuquan Wei   +12 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Urban agglomerations environmental heterogeneity and heatwave risks: spatiotemporal insights from remote sensing and public sentiment analysis

Geomatics, Natural Hazards & Risk
Urban agglomerations are global hotspots for escalating heatwave risks, where the complex interplay between environmental drivers and public emotional responses remains underexplored due to limitations in traditional research methods and data on heatwave
Shengxiang Shi, Yi Chai, Qing Ye, Jialiang Kang, Qinglong Zhang   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source